Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00852)
Xenobiotics Name
Allyl isothiocyanate
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Acute Toxic Substance
Structure
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3D MOL 2D MOL
PubChem CID
5971
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [1]
Glutathione reductase (GSR) DME Info Homo sapiens [2]
NADPH-dependent oxidoreductase (nfrA) DME Info Staphylococcus aureus [3]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [2]
References
1 Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity. Arch Toxicol. 2015 Jan;89(1):57-72.
2 Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents. Biol Chem. 2007 Oct;388(10):1069-81.
3 Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus. Appl Microbiol Biotechnol. 2014 Nov;98(22):9447-57.

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