Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00858)
Xenobiotics Name
Flavonoids
Xenobiotics Type
Natural Product(s), Extract(s) or Medicine(s)
Classification
Natural Mixture
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Carbonic anhydrase II (CA2) DME Info Homo sapiens [1]
Aromatase (CYP19A1) DME Info Homo sapiens [2]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [3]
D-Lactate dehydrogenase (ldhA) DME Info Pseudomonas aeruginosa [4]
Arylamine N-acetyltransferase (NAT) DME Info Pseudomonas aeruginosa [4]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info Pseudomonas aeruginosa [4]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [5]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [6]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [5]
References
1 Inhibition properties of some flavonoids on carbonic anhydrase I and II isoenzymes purified from human erythrocytes. J Biochem Mol Toxicol. 2017 Sep;31(9).
2 Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. Toxicol Sci. 2004 Nov;82(1):70-9.
3 Epicatechin and a cocoa polyphenolic extract modulate gene expression in human Caco-2 cells. J Nutr. 2004 Oct;134(10):2509-16.
4 A medicinal herb Cassia alata attenuates quorum sensing in Chromobacterium violaceum and Pseudomonas aeruginosa. Lett Appl Microbiol. 2017 Mar;64(3):231-238.
5 The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics. Biochem Pharmacol. 2004 Mar 1;67(5):989-1000.
6 Flavonoids from persimmon (Diospyros kaki L.) leaves inhibit proliferation and induce apoptosis in PC-3ells by activation of oxidative stress and mitochondrial apoptosis. Chem Biol Interact. 2017 Sep 25;275:210-217.

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