Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00871)
Xenobiotics Name
9,10-phenanthrenequinone
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Investigative Agent
Structure
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3D MOL 2D MOL
PubChem CID
6763
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Small intestine reductase (AKR1B10) DME Info Homo sapiens [2]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [3]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [3]
References
1 9,10-Phenanthraquinone in diesel exhaust particles downregulates Cu,Zn-SOD and HO-1 in human pulmonary epithelial cells: intracellular iron scavenger 1,10-phenanthroline affords protection against apoptosis. Free Radic Biol Med. 2005 Feb 1;38(3):388-95.
2 Exposure to 9,10-phenanthrenequinone accelerates malignant progression of lung cancer cells through up-regulation of aldo-keto reductase 1B10. Toxicol Appl Pharmacol. 2014 Jul 15;278(2):180-9.
3 Facilitation of 9,10-phenanthrenequinone-elicited neuroblastoma cell apoptosis by NAD(P)H:quinone oxidoreductase 1. Chem Biol Interact. 2018 Jan 5;279:10-20.

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