Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00876)
Xenobiotics Name
Arachidonic acid
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Investigative Agent
Structure
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3D MOL 2D MOL
PubChem CID
444899
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Carboxylesterase 1 (CES1) DME Info Homo sapiens [1]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [2]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [2]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [2]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [2]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [2]
Fatty acid desaturase 2 (FADS2) DME Info Homo sapiens [3]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [4]
Serum paraoxonase/arylesterase 1 (PON1) DME Info Homo sapiens [5]
DME(s) Induced by This Xenobiotics
Cytosolic phospholipase A2 (PLA2G4A) DME Info Homo sapiens [6]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [7], [8]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [6], [8]
References
1 Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. Biochim Biophys Acta. 2010 Jan;1801(1):31-41.
2 The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes. Life Sci. 2006 Nov 25;79(26):2432-40.
3 Regulation of stearoyl-coenzyme A desaturase and fatty acid delta-6 desaturase-2 expression by linoleic acid and arachidonic acid in human sebocytes leads to enhancement of proinflammatory activity but does not affect lipogenesis. Br J Dermatol. 2011 Aug;165(2):269-76.
4 Arachidonic acid-induced gene expression in colon cancer cells. Carcinogenesis. 2006 Oct;27(10):1950-60.
5 Preferential inhibition of paraoxonase activity of human paraoxonase 1 by negatively charged lipids. J Lipid Res. 2004 Dec;45(12):2211-20.
6 Arachidonic acid, an omega-6 fatty acid, induces cytoplasmic phospholipase A2 in prostate carcinoma cells. Carcinogenesis. 2005 Sep;26(9):1520-6.
7 Resveratrol inhibits prostaglandin formation in IL-1beta-stimulated SK-N-SH neuronal cells. J Neuroinflammation. 2009 Sep 14;6:26.
8 Human prostaglandin H synthase (hPHS)-1 and hPHS-2 in amphetamine analog bioactivation, DNA oxidation, and cytotoxicity. Toxicol Sci. 2011 Mar;120(1):154-62.

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