Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01023)
Xenobiotics Name
Sodium arsenate
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Environmental Pollutant
Structure
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3D MOL 2D MOL
PubChem CID
23677060
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Short-chain dehydrogenase/reductase retSDR1 (DHRS3) DME Info Homo sapiens [1]
Glutamine synthetase (GLUL) DME Info Homo sapiens [2]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1B1 (AKR1B1) DME Info Homo sapiens [4]
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [5]
Asparagine synthetase (ASNS) DME Info Homo sapiens [6]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [4]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [7]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [7]
References
1 Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases. Drug Metab Dispos. 2004 Jun;32(6):587-94.
2 The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes. Chem Biol Interact. 2017 Jun 1;271:24-29.
3 AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids. Chem Biol Interact. 2009 Mar 16;178(1-3):138-44.
4 RNA-sequencing reveals long-term effects of silver nanoparticles on human lung cells. Sci Rep. 2018 Apr 27;8(1):6668.
5 Differential genotoxicity mechanisms of silver nanoparticles and silver ions. Arch Toxicol. 2017 Jan;91(1):509-519.
6 Global gene expression profiling of human lung epithelial cells after exposure to nanosilver. Toxicol Sci. 2012 Nov;130(1):145-57.
7 Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells. Toxicol In Vitro. 2009 Sep;23(6):1076-84.

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