Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01046)
Xenobiotics Name
Cypermethrin
Xenobiotics Type
Fungicide(s), Herbicide(s) or Insecticide(s)
Classification
Pesticide/Insecticide
Structure
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3D MOL 2D MOL
PubChem CID
2912
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aminomuconic semialdehyde dehydrogenase (ALDH12) DME Info Homo sapiens [1]
Catalase (CAT) DME Info Homo sapiens [2]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [3]
Cytochrome P450 2D6 (CYP2D6) DME Info Homo sapiens [3]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [4]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [3], [4]
DME(s) Induced by This Xenobiotics
Aromatase (CYP19A1) DME Info Homo sapiens [5]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [6]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [7], [6]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [6]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [6]
References
1 Successful validation of genomic biomarkers for human immunotoxicity in Jurkat T cells in vitro. J Appl Toxicol. 2015 Jul;35(7):831-41.
2 Immunological and genotoxic effects of occupational exposure to alpha-cypermethrin pesticide. Int J Occup Med Environ Health. 2017 Jun 19;30(4):603-615.
3 Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening. Drug Metab Dispos. 2008 Jul;36(7):1322-31.
4 The inhibition of major human hepatic cytochrome P450 enzymes by 18 pesticides: comparison of the N-in-one and single substrate approaches. Toxicol In Vitro. 2013 Aug;27(5):1584-8.
5 Modulation of aromatase activity and mRNA by various selected pesticides in the human choriocarcinoma JEG-3 cell line. Toxicology. 2006 Nov 10;228(1):98-108.
6 Characterization of human cytochrome P450 induction by pesticides. Toxicology. 2012 Mar 29;294(1):17-26.
7 A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides. Biochem Pharmacol. 2004 Dec 15;68(12):2347-58.

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