Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01074)
Xenobiotics Name
Endosulfan
Xenobiotics Type
Fungicide(s), Herbicide(s) or Insecticide(s)
Classification
Pesticide/Insecticide
Structure
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3D MOL 2D MOL
PubChem CID
3224
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Alcohol dehydrogenase class-I alpha (ADH1A) DME Info Homo sapiens [1]
Alcohol dehydrogenase class-I beta (ADH1B) DME Info Homo sapiens [1]
Alcohol dehydrogenase class-II (ADH4) DME Info Homo sapiens [2]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [3]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [2]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [4]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [5]
Tryptophan 5-hydroxylase 1 (TPH1) DME Info Homo sapiens [5]
DME(s) Induced by This Xenobiotics
Arachidonate 12-lipoxygenase (ALOX12B) DME Info Homo sapiens [6]
Arachidonate 5-lipoxygenase (ALOX5) DME Info Homo sapiens [5]
Aromatase (CYP19A1) DME Info Homo sapiens [7]
Retinoic acid 4-hydroxylase 26A1 (CYP26A1) DME Info Homo sapiens [5], [8]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [4]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [9]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [10]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [5]
References
1 Two persistent organic pollutants which act through different xenosensors (alpha-endosulfan and 2,3,7,8 tetrachlorodibenzo-p-dioxin) interact in a mixture and downregulate multiple genes involved in human hepatocyte lipid and glucose metabolism. Biochimie. 2015 Sep;116:79-91.
2 Down-regulation of the expression of alcohol dehydrogenase 4 and CYP2E1 by the combination of alpha-endosulfan and dioxin in HepaRG human cells. Toxicol In Vitro. 2017 Dec;45(Pt 3):309-317.
3 Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7. Cancer Res. 2001 May 15;61(10):3942-8.
4 Interactions of endosulfan and methoxychlor involving CYP3A4 and CYP2B6 in human HepaRG cells. Drug Metab Dispos. 2014 Aug;42(8):1235-40.
5 An integrated genomic and proteomic approach to identify signatures of endosulfan exposure in hepatocellular carcinoma cells. Pestic Biochem Physiol. 2015 Nov;125:8-16.
6 Exposure to endosulfan increases endothelial permeability by transcellular and paracellular pathways in relation to cardiovascular diseases. Environ Pollut. 2017 Apr;223:111-119.
7 Modulation of aromatase activity and mRNA by various selected pesticides in the human choriocarcinoma JEG-3 cell line. Toxicology. 2006 Nov 10;228(1):98-108.
8 Activation of retinoic acid receptor-dependent transcription by organochlorine pesticides. Toxicol Appl Pharmacol. 2005 Jan 1;202(1):38-49.
9 Organochlorine pesticide-mediated induction of NADPH oxidase and nitric-oxide synthase in endothelial cell. J Clin Diagn Res. 2017 Jan;11(1):BC09-BC12.
10 Cellular impact of combinations of endosulfan, atrazine, and chlorpyrifos on human primary hepatocytes and HepaRG cells after short and chronic exposures. Cell Biol Toxicol. 2014 Feb;30(1):17-29.

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