Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01103)
Xenobiotics Name
1-methyl-4-phenylpyridinium
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Health Hazard/Toxicant
Structure
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3D MOL 2D MOL
PubChem CID
39484
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Acetylcholinesterase (ACHE) DME Info Homo sapiens [1]
Dicarbonyl/L-xylulose reductase (DCXR) DME Info Homo sapiens [2]
Dihydrofolate reductase (DHFR) DME Info Homo sapiens [3]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [4]
NADH-ubiquinone oxidoreductase 30 kDa (NDUFS3) DME Info Homo sapiens [5], [2]
Thymidylate synthase (TYMS) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Asparagine synthetase (ASNS) DME Info Homo sapiens [2]
Cytosolic branched aminotransferase (BCAT1) DME Info Homo sapiens [3]
Serine sulfhydrase (CBS) DME Info Homo sapiens [3]
Vitamin D 25-hydroxylase (CYP2R1) DME Info Homo sapiens [3]
Galactose kinase (GALK1) DME Info Homo sapiens [3]
Hexosephosphate aminotransferase 2 (GFPT2) DME Info Homo sapiens [3]
N-acetyl-beta-glucosaminidase beta (HEXB) DME Info Homo sapiens [3]
Myeloperoxidase (MPO) DME Info Homo sapiens [3]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [6]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [3]
Phosphorylethanolamine transferase (PCYT2) DME Info Homo sapiens [3]
References
1 Bone loss in MPTP mouse model of Parkinson's disease is triggered by decreased osteoblastogenesis and increased osteoclastogenesis. Toxicol Appl Pharmacol. 2019 Jan 15;363:154-163.
2 Quantitative proteomic analysis reveals mitochondrial protein changes in MPP(+)-induced neuronal cells. Mol Biosyst. 2014 Jul;10(7):1940-7.
3 Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+). Cell Death Dis. 2014 May 8;5:e1222.
4 Neurotoxin-induced pathway perturbation in human neuroblastoma SH-EP cells. Mol Cells. 2014 Sep;37(9):672-84.
5 Mitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis. Mol Biosyst. 2014 Jun;10(6):1332-44.
6 The neuroprotective role of insulin against MPP(+) -induced Parkinson's disease in differentiated SH-SY5Y cells. J Cell Biochem. 2016 Apr;117(4):917-26.

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