Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01119)
Xenobiotics Name
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Acute Toxic Substance
Structure
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3D MOL 2D MOL
PubChem CID
1530
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Arachidonate 5-lipoxygenase (ALOX5) DME Info Homo sapiens [1]
Calcidiol 1-monooxygenase (CYP27B1) DME Info Homo sapiens [1]
DOPA decarboxylase (DDC) DME Info Homo sapiens [2]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [3]
S-adenosylmethionine synthase 2 (MAT2A) DME Info Homo sapiens [1]
N-acetyltransferase 2 (NAT2) DME Info Homo sapiens [3]
Sulfotransferase 1A1 (SULT1A1) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Choline O-acetyltransferase (CHAT) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [4]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [5]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [4]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [5]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [6]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [7]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [3], [8]
References
1 Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines. Toxicol Appl Pharmacol. 2010 Nov 15;249(1):91-100.
2 Inhibition of human brain aromatic L-amino acid decarboxylase by cooked food-derived 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and other heterocyclic amines. Neurosci Lett. 1990 Aug 24;116(3):372-8.
3 Protective effects of xanthohumol against the genotoxicity of heterocyclic aromatic amines MeIQx and PhIP in bacteria and in human hepatoma (HepG2) cells. Food Chem Toxicol. 2012 Mar;50(3-4):949-55.
4 Differential toxicity of heterocyclic aromatic amines and their mixture in metabolically competent HepaRG cells. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):256-63.
5 Ethanol potentiates the genotoxicity of the food-derived mammary carcinogen PhIP in human estrogen receptor-positive mammary cells: mechanistic support for lifestyle factors (cooked red meat and ethanol) associated with mammary cancer. Arch Toxicol. 2018 Apr;92(4):1639-1655.
6 Adipose tissue stem cell-derived hepatic progenies as an in vitro model for genotoxicity testing. Arch Toxicol. 2018 May;92(5):1893-1903.
7 The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine promotes invasive behaviour of breast cancer cells. Toxicology. 2011 Jan 11;279(1-3):139-45.
8 Genotoxicity and induction of DNA damage responsive genes by food-borne heterocyclic aromatic amines in human hepatoma HepG2 cells. Food Chem Toxicol. 2013 Sep;59:386-94.

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