Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01129)
Xenobiotics Name
2-tert-butylhydroquinone
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Environmental Pollutant
Structure
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3D MOL 2D MOL
PubChem CID
16043
DME(s) Modulated by This Xenobiotics
DME(s) Induced by This Xenobiotics
Small intestine reductase (AKR1B10) DME Info Homo sapiens [1]
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [2], [1]
Carboxylesterase 1 (CES1) DME Info Homo sapiens [3]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [4], [5]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [6]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [6]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [6]
Glutathione reductase (GSR) DME Info Homo sapiens [7]
Glutathione S-transferase mu-1 (GSTM1) DME Info Homo sapiens [8]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [9]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [10]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [11], [1]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info Homo sapiens [12]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info Homo sapiens [13]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info Homo sapiens [13]
References
1 The THP-1 cell toolbox: a new concept integrating the key events of skin sensitization. Arch Toxicol. 2019 Apr;93(4):941-951.
2 Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
3 Transcriptional regulation of human carboxylesterase 1A1 by nuclear factor-erythroid 2 related factor 2 (Nrf2). Biochem Pharmacol. 2010 Jan 15;79(2):288-95.
4 tert-Butylhydroquinone is a novel aryl hydrocarbon receptor ligand. Drug Metab Dispos. 2005 Mar;33(3):365-72.
5 Regulation of CYP1A1 gene expression by the antioxidant tert-butylhydroquinone. Drug Metab Dispos. 2006 Jul;34(7):1096-101.
6 Regulation of human CYP2C9 expression by electrophilic stress involves activator protein 1 activation and DNA looping. Mol Pharmacol. 2014 Aug;86(2):125-37.
7 Regulation of the glyoxalase pathway in human brain microvascular endothelium: effects of troglitazone and tertiary butylhydroperoxide. Endothelium. 2002;9(4):273-8.
8 tBHQ-induced HO-1 expression is mediated by calcium through regulation of Nrf2 binding to enhancer and polymerase II to promoter region of HO-1. Chem Res Toxicol. 2011 May 16;24(5):670-6.
9 Expression of glutathione S-transferase P1-1 in leukemic cells is regulated by inducible AP-1 binding. Cancer Lett. 2004 Dec 28;216(2):207-19.
10 The electrophilic character of quinones is essential for the suppression of Bach1. Toxicology. 2017 Jul 15;387:17-26.
11 Thioredoxin reductase in human hepatoma cells is transcriptionally regulated by sulforaphane and other electrophiles via an antioxidant response element. J Nutr. 2003 Sep;133(9):2721-7.
12 Contribution of the Ah receptor to the phenolic antioxidant-mediated expression of human and rat UDP-glucuronosyltransferase UGT1A6 in Caco-2 and rat hepatoma 5L cells. Biochem Pharmacol. 2003 Sep 1;66(5):841-7.
13 Induction of human UDP glucuronosyltransferases (UGT1A6, UGT1A9, and UGT2B7) by t-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin in Caco-2 cells. Drug Metab Dispos. 1999 May;27(5):569-73.

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