General Information of Xenobiotics (ID: XEO01133)
Xenobiotics Name
3,3',4,5'-tetrahydroxystilbene
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Investigative Agent
Structure
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3D MOL 2D MOL
PubChem CID
667639
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cholesterol desmolase (CYP11A1) DME Info Homo sapiens [1]
Steroid 17-alpha-monooxygenase (CYP17A1) DME Info Homo sapiens [1]
Steroid 21-hydroxylase (CYP21A2) DME Info Homo sapiens [1]
Beta-HSD adrenal and gonadal type (HSD3B2) DME Info Homo sapiens [1]
Sulfotransferase 1E1 (SULT1E1) DME Info Homo sapiens [1]
Sulfotransferase 2A1 (SULT2A1) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [3]
References
1 Inhibition of CYP17A1 activity by resveratrol, piceatannol, and synthetic resveratrol analogs. Prostate. 2014 Jun;74(8):839-51.
2 Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes. Food Chem Toxicol. 2017 May;103:122-132.
3 Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules. Toxicol In Vitro. 2018 Oct;52:222-234.

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