Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01166)
Xenobiotics Name
6',7'-dihydroxybergamottin
Xenobiotics Type
Natural Product(s), Extract(s) or Medicine(s)
Classification
Natural Product
Structure
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3D MOL 2D MOL
PubChem CID
6440498
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [1]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [2]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [3]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 3A4 (CYP3A4) DME Info IC50 = 0.81 microM [2]
References
1 Inhibition of human and rat CYP1A1 enzyme by grapefruit juice compounds. Toxicol Lett. 2016 Sep 6;258:267-275.
2 Biotransformations of 6',7'-dihydroxybergamottin and 6',7'-epoxybergamottin by the citrus-pathogenic fungi diminish cytochrome P450 3A4 inhibitory activity. Bioorg Med Chem Lett. 2012 Mar 15;22(6):2279-82.
3 Inhibition of CYP3A4 by 6',7'-dihydroxybergamottin in human CYP3A4 over-expressed hepG2 cells. J Pharm Pharmacol. 2012 Dec;64(12):1715-21.

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