Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01195)
Xenobiotics Name
Amentoflavone
Xenobiotics Type
Natural Product(s), Extract(s) or Medicine(s)
Classification
Natural Product
Structure
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3D MOL 2D MOL
PubChem CID
5281600
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [1]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [2]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 1A10 (UGT1A10) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 1A7 (UGT1A7) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 1A8 (UGT1A8) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info Homo sapiens [3]
References
1 Inhibition of human cytochrome CYP 1 enzymes by flavonoids of StJohn's wort. Toxicology. 2006 Jan 16;217(2-3):194-205.
2 Downregulation of COX-2 and iNOS by amentoflavone and quercetin in A549 human lung adenocarcinoma cell line. Prostaglandins Leukot Essent Fatty Acids. 2002 May-Jun;66(5-6):485-92.
3 Amentoflavone is a potent broad-spectrum inhibitor of human UDP-glucuronosyltransferases. Chem Biol Interact. 2018 Mar 25;284:48-55.

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