Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01208)
Xenobiotics Name
HI-6
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Preclinical/Patented Drug
Structure
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3D MOL 2D MOL
PubChem CID
91614
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Acetylcholinesterase (ACHE) DME Info Homo sapiens [1], [2]
Butyrylcholine esterase (BCHE) DME Info Homo sapiens [2]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [3]
References
1 Interactions of pyridinium oximes with acetylcholinesterase. Chem Biol Interact. 2010 Sep 6;187(1-3):172-6.
2 Pyridoxal oxime derivative potency to reactivate cholinesterases inhibited by organophosphorus compounds. Toxicol Lett. 2016 Nov 16;262:114-122.
3 Effect of acetylcholinesterase oxime-type reactivators K-48 and HI-6 on human liver microsomal cytochromes P450 in vitro. Chem Biol Interact. 2009 Aug 14;180(3):449-53.

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