Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01219)
Xenobiotics Name
MG-132
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Investigative Agent
Structure
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3D MOL 2D MOL
PubChem CID
462382
DME(s) Modulated by This Xenobiotics
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1B1 (AKR1B1) DME Info Homo sapiens [1]
Small intestine reductase (AKR1B10) DME Info Homo sapiens [1]
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [1], [2]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [1], [2]
Glutathione S-transferase alpha-2 (GSTA2) DME Info Homo sapiens [3]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [4]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [5]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [6]
References
1 Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29. Chem Biol Interact. 2011 May 30;191(1-3):239-49.
2 Pathophysiological roles of aldo-keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers. Chem Biol Interact. 2013 Feb 25;202(1-3):234-42.
3 Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response elementDegradation of Nrf2 by the 26 S proteasome. J Biol Chem. 2003 Feb 14;278(7):4536-41.
4 Selective induction of the tumor marker glutathione S-transferase P1 by proteasome inhibitors. J Biol Chem. 2005 Jul 1;280(26):25267-76.
5 A p38-p65 transcription complex induced by endothelin-1 mediates signal transduction in cancer cells. Biochim Biophys Acta. 2008 Sep;1783(9):1613-22.
6 BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite. J Biol Chem. 2008 Aug 15;283(33):22363-70.

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