Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01226)
Xenobiotics Name
Bisphenol A
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 2 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
6623
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Porphobilinogen synthase (ALAD) DME Info Homo sapiens [1]
Aldehyde dehydrogenase 5 (ALDHX) DME Info Homo sapiens [2]
Alkaline phosphatase (ALPL) DME Info Homo sapiens [3]
Copper amine oxidase (AOC3) DME Info Homo sapiens [4]
Arsenite methyltransferase (AS3MT) DME Info Homo sapiens [5]
Asparagine synthetase (ASNS) DME Info Homo sapiens [6], [7]
Bleomycin hydrolase (BLMH) DME Info Homo sapiens [2]
Catalase (CAT) DME Info Homo sapiens [8]
Serine sulfhydrase (CBS) DME Info Homo sapiens [6]
Carboxylesterase 2 (CES2) DME Info Homo sapiens [9]
Catechol O-methyltransferase (COMT) DME Info Homo sapiens [9], [10]
Cholesterol desmolase (CYP11A1) DME Info Homo sapiens [11], [12]
Aldosterone synthase (CYP11B2) DME Info Homo sapiens [13]
Steroid 17-alpha-monooxygenase (CYP17A1) DME Info Homo sapiens [14], [15]
Aromatase (CYP19A1) DME Info Homo sapiens [16]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [17]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [18]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [18]
Dihydrofolate reductase (DHFR) DME Info Homo sapiens [2]
Short-chain dehydrogenase/reductase retSDR1 (DHRS3) DME Info Homo sapiens [19]
Thymidylate kinase (DTYMK) DME Info Homo sapiens [2]
Oleamide hydrolase 1 (FAAH) DME Info Homo sapiens [20], [21]
Gamma-Glu-X carboxypeptidase (GGH) DME Info Homo sapiens [2]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [22]
Glutathione S-transferase omega-1 (GSTO1) DME Info Homo sapiens [2]
Hypoxanthine phosphoribosyltransferase (HPRT1) DME Info Homo sapiens [2]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info Homo sapiens [23]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [23]
Estradiol 17-beta-dehydrogenase 1 (HSD17B1) DME Info Homo sapiens [24]
Testicular 17-beta-hydroxysteroid dehydrogenase (HSD17B3) DME Info Homo sapiens [15]
Beta-HSD adrenal and gonadal type (HSD3B2) DME Info Homo sapiens [11]
Neprilysin (MME) DME Info Homo sapiens [6]
Methionine-R-sulfoxide reductase B2 (MSRB2) DME Info Homo sapiens [25]
Metallothionein-2A (MT2A) DME Info Homo sapiens [26]
Phosphoribosylformylglycinamidine synthase (PFAS) DME Info Homo sapiens [2]
Choline phosphatase 1 (PLD1) DME Info Homo sapiens [6]
Purine nucleoside phosphorylase (PNP) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [4]
Sulfotransferase 1B1 (SULT1B1) DME Info Homo sapiens [9]
Sulfotransferase 1E1 (SULT1E1) DME Info Homo sapiens [27]
Sulfotransferase 2A1 (SULT2A1) DME Info Homo sapiens [9]
Transglutaminase H (TGM2) DME Info Homo sapiens [2]
Thymidine phosphorylase (TYMP) DME Info Homo sapiens [6]
Thymidylate synthase (TYMS) DME Info Homo sapiens [2]
UDP-glucuronosyltransferase 1A10 (UGT1A10) DME Info Homo sapiens [9]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info Homo sapiens [17], [9]
UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info Homo sapiens [9]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info Homo sapiens [9]
UDP-glucuronosyltransferase 1A8 (UGT1A8) DME Info Homo sapiens [9]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info Homo sapiens [9]
Uridine 5'-monophosphate synthase (UMPS) DME Info Homo sapiens [2]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [6]
VKORC1-like protein 1 (VKORC1L1) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Acetylcholinesterase (ACHE) DME Info Homo sapiens [28], [29]
Alcohol dehydrogenase class-I gamma (ADH1C) DME Info Homo sapiens [2]
Hydroxyacid-oxoacid transhydrogenase (ADHFE1) DME Info Homo sapiens [2]
Aldehyde dehydrogenase 2 (ALDH2) DME Info Homo sapiens [2]
Aldehyde dehydrogenase 7 (ALDH7) DME Info Homo sapiens [2]
Arylsulfatase A (ARSA) DME Info Homo sapiens [2]
Beta,beta-carotene 15,15'-dioxygenase (BCO1) DME Info Homo sapiens [19]
Carbonic anhydrase II (CA2) DME Info Homo sapiens [30]
Carboxylesterase 1 (CES1) DME Info Homo sapiens [4]
Cathepsin A (CTSA) DME Info Homo sapiens [2]
Microsomal cytochrome MCB5 (CYB5A) DME Info Homo sapiens [6]
Steroid 11-beta-hydroxylase (CYP11B1) DME Info Homo sapiens [13]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [16], [31]
Vitamin D(3) 25-hydroxylase (CYP27A1) DME Info Homo sapiens [4], [2]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [32]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [32]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [32]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [32]
Delta(24)-sterol reductase (DHCR24) DME Info Homo sapiens [2]
Dipeptidyl peptidase IV (DPP4) DME Info Homo sapiens [4], [2]
Fatty acid desaturase 1 (FADS1) DME Info Homo sapiens [2]
Fatty acid desaturase 2 (FADS2) DME Info Homo sapiens [2]
Dimethylaniline oxidase 1 (FMO1) DME Info Homo sapiens [4]
Glutamyl-tRNA(Gln) amidotransferase B (GATB) DME Info Homo sapiens [2]
Glutathione reductase (GSR) DME Info Homo sapiens [2]
N-acetyl-beta-glucosaminidase beta (HEXB) DME Info Homo sapiens [33]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [34]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [35]
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [2]
Methylenetetrahydrofolate reductase (MTHFR) DME Info Homo sapiens [2]
Glutamine-dependent NAD(+) synthetase (NADSYN1) DME Info Homo sapiens [7]
NADH-ubiquinone oxidoreductase 30 kDa (NDUFS3) DME Info Homo sapiens [7]
Nitric oxide synthase brain (NOS1) DME Info Homo sapiens [36]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [36]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [37]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [2]
Ecto-5'-nucleotidase (NT5E) DME Info Homo sapiens [19]
Phosphorylethanolamine transferase (PCYT2) DME Info Homo sapiens [2]
Phosphodiesterase 5A (PDE5A) DME Info Homo sapiens [2]
Phosphoglucomutase 1 (PGM1) DME Info Homo sapiens [2]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [38]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [26]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [39]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [2]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [31]
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info Homo sapiens [40]
References
1 Evaluation of estrogen receptor alpha activation by glyphosate-based herbicide constituents. Food Chem Toxicol. 2017 Oct;108(Pt A):30-42.
2 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
3 Cultured human peripheral blood mononuclear cells alter their gene expression when challenged with endocrine-disrupting chemicals. Toxicology. 2013 Jan 7;303:17-24.
4 Bisphenol A and bisphenol S induce distinct transcriptional profiles in differentiating human primary preadipocytes. PLoS One. 2016 Sep 29;11(9):e0163318.
5 Gene expression profiling analysis of bisphenol A-induced perturbation in biological processes in ER-negative HEK293 cells. PLoS One. 2014 Jun 5;9(6):e98635.
6 Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells. Toxicol Appl Pharmacol. 2010 Oct 15;248(2):111-21.
7 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
8 Bisphenol A, bisphenol S, bisphenol F and bisphenol AF induce different oxidative stress and damage in human red blood cells (in vitro study). Toxicol In Vitro. 2017 Jun;41:143-149.
9 Bisphenol A-associated alterations in the expression and epigenetic regulation of genes encoding xenobiotic metabolizing enzymes in human fetal liver. Environ Mol Mutagen. 2014 Apr;55(3):184-95.
10 Assessment of cellular estrogenic activity based on estrogen receptor-mediated reduction of soluble-form catechol-O-methyltransferase (COMT) expression in an ELISA-based system. PLoS One. 2013 Sep 6;8(9):e74065.
11 Does BPA alter steroid hormone synthesis in human granulosa cells in vitro? Hum Reprod. 2016 Jul;31(7):1562-9.
12 Low-dose bisphenol A activates the ERK signaling pathway and attenuates steroidogenic gene expression in human placental cells. Biol Reprod. 2018 Feb 1;98(2):250-258.
13 Effects of bisphenol analogues on steroidogenic gene expression and hormone synthesis in H295R cells. Chemosphere. 2016 Mar;147:9-19.
14 Bisphenol A disrupts steroidogenesis in human H295R cells. Toxicol Sci. 2011 Jun;121(2):320-7.
15 Inhibition of human and rat testicular steroidogenic enzyme activities by bisphenol A. Toxicol Lett. 2011 Nov 30;207(2):137-42.
16 Bisphenol A affects estradiol metabolism by targeting CYP1A1 and CYP19A1 in human placental JEG-3 cells. Toxicol In Vitro. 2019 Dec;61:104615.
17 Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
18 Inhibition of drug-metabolizing enzyme activity in human hepatic cytochrome P450s by bisphenol A. Biol Pharm Bull. 2000 Apr;23(4):498-501.
19 Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure. Int J Oncol. 2012 Jul;41(1):369-77.
20 Bisphenol A induces fatty liver by an endocannabinoid-mediated positive feedback loop. Endocrinology. 2016 May;157(5):1751-63.
21 Evaluation of bisphenol A influence on endocannabinoid system in pregnant women. Chemosphere. 2018 Jul;203:387-392.
22 Prenatal nonylphenol and bisphenol A exposures and inflammation are determinants of oxidative/nitrative stress: a taiwanese cohort study. Environ Sci Technol. 2017 Jun 6;51(11):6422-6429.
23 Inhibition of human and rat 11beta-hydroxysteroid dehydrogenases activities by bisphenol A. Toxicol Lett. 2012 Nov 30;215(2):126-30.
24 Effect of bisphenol A on human endometrial stromal fibroblasts in vitro. Reprod Biomed Online. 2011 Mar;22(3):249-56.
25 Genome-wide gene expression profiling of low-dose, long-term exposure of human osteosarcoma cells to bisphenol A and its analogs bisphenols AF and S. Toxicol In Vitro. 2015 Aug;29(5):1060-9.
26 Low dose of bisphenol a modulates ovarian cancer gene expression profile and promotes epithelial to mesenchymal transition via canonical Wnt pathway. Toxicol Sci. 2018 Aug 1;164(2):527-538.
27 Effects of endocrine disruptors on genes associated with 17beta-estradiol metabolism and excretion. Steroids. 2008 Nov;73(12):1242-51.
28 The in vitro comparative study of the effect of BPA, BPS, BPF and BPAF on human erythrocyte membrane; perturbations in membrane fluidity, alterations in conformational state and damage to proteins, changes in ATP level and Na+/K+ ATPase and AChE activities. Food Chem Toxicol. 2017 Dec;110:351-359.
29 Low-dose bisphenol A induces RIPK1-mediated necroptosis in SH-SY5Y cells: Effects on TNF-alpha and acetylcholinesterase. J Biochem Mol Toxicol. 2018 Sep 21:e22233.
30 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
31 Genotoxic activity of bisphenol A and its analogues bisphenol S, bisphenol F and bisphenol AF and their mixtures in human hepatocellular carcinoma (HepG2) cells. Sci Total Environ. 2019 Oct 15;687:267-276.
32 Environmental pollutants parathion, paraquat and bisphenol A show distinct effects towards nuclear receptors-mediated induction of xenobiotics-metabolizing cytochromes P450 in human hepatocytes. Toxicol Lett. 2015 Oct 1;238(1):43-53.
33 Expression of TNF-alpha and IL-6 in HMC-1 cells treated with bisphenol A is attenuated by plant-originating glycoprotein (75 kDa) by blocking p38 MAPK. Naunyn Schmiedebergs Arch Pharmacol. 2010 Jul;382(1):51-61.
34 Bisphenol A induces cholesterol biosynthesis in HepG2 cells via SREBP-2/HMGCR signaling pathway. J Toxicol Sci. 2019;44(7):481-491.
35 Oestrogenic potencies of Zeranol, oestradiol, diethylstilboestrol, Bisphenol-A and genistein: implications for exposure assessment of potential endocrine disrupters. Hum Reprod. 2001 May;16(5):1037-45.
36 Bisphenol-A exposure induced neurotoxicity in glutamatergic neurons derived from human embryonic stem cells. Environ Int. 2019 Jun;127:324-332.
37 Bisphenol A modulates inflammation and proliferation pathway in human endometrial stromal cells by inducing oxidative stress. Reprod Toxicol. 2018 Oct;81:41-49.
38 Bisphenol A induces COX-2 through the mitogen-activated protein kinase pathway and is associated with levels of inflammation-related markers in elderly populations. Environ Res. 2017 Oct;158:490-498.
39 Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells. Carcinogenesis. 2017 Mar 1;38(3):252-260.
40 Effects of triclocarban on the transcription of estrogen, androgen and aryl hydrocarbon receptor responsive genes in human breast cancer cells. Toxicol In Vitro. 2013 Aug;27(5):1467-75.

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