Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01233)
Xenobiotics Name
Phenethyl caffeate
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 1 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
5281787
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldo-keto reductase 1B1 (AKR1B1) DME Info Homo sapiens [1]
Small intestine reductase (AKR1B10) DME Info Homo sapiens [1]
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [2]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [2]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [2]
Aldo-keto reductase 1C4 (AKR1C4) DME Info Homo sapiens [2]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Aldo-keto reductase 1B1 (AKR1B1) DME Info IC50 = 0.57 microM [1]
Small intestine reductase (AKR1B10) DME Info IC50 = 0.08 microM [1]
Aldo-keto reductase 1C1 (AKR1C1) DME Info IC50 = 13 microM [2]
Aldo-keto reductase 1C2 (AKR1C2) DME Info IC50 = 6 microM [2]
Aldo-keto reductase 1C3 (AKR1C3) DME Info IC50 = 1.7 microM [2]
Aldo-keto reductase 1C4 (AKR1C4) DME Info IC50 = 2.3 microM [2]
References
1 Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B10. Eur J Med Chem. 2012 Feb;48:321-9.
2 Selective inhibition of human type-5 17beta-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis. J Nat Prod. 2012 Apr 27;75(4):716-21.

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