Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01268)
Xenobiotics Name
Cycloheximide
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Acute Toxic Substance
Structure
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3D MOL 2D MOL
PubChem CID
6197
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aromatase (CYP19A1) DME Info Homo sapiens [1]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [2]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [3]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [4]
Thymidine phosphorylase (TYMP) DME Info Homo sapiens [5]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [6]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [7]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [7]
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info Homo sapiens [8]
References
1 Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition. J Med Chem. 2006 Feb 23;49(4):1413-9.
2 Metabolism of bilirubin by human cytochrome P450 2A6. Toxicol Appl Pharmacol. 2012 May 15;261(1):50-8.
3 The effect of interferon-alpha on the expression of cytochrome P450 3A4 in human hepatoma cells. Toxicol Appl Pharmacol. 2011 Jun 1;253(2):130-6.
4 Instability of the human cytochrome p450 reductase A287P variant is the major contributor to its antley-bixler syndrome-like phenotype. J Biol Chem. 2016 Sep 23;291(39):20487-502.
5 Inhibition of thymidine phosphorylase expression by Hsp90 inhibitor potentiates the cytotoxic effect of salinomycin in human non-small-cell lung cancer cells. Toxicology. 2019 Apr 1;417:54-63.
6 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
7 Comparative analysis of AhR-mediated TCDD-elicited gene expression in human liver adult stem cells. Toxicol Sci. 2009 Nov;112(1):229-44.
8 Estrogen regulation of the glucuronidation enzyme UGT2B15 in estrogen receptor-positive breast cancer cells. Endocrinology. 2006 Aug;147(8):3843-50.

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