Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01305)
Xenobiotics Name
Formaldehyde
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Acute Toxic Substance
Structure
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3D MOL 2D MOL
PubChem CID
712
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Small intestine reductase (AKR1B10) DME Info Homo sapiens [1]
Aldehyde dehydrogenase 5 (ALDHX) DME Info Homo sapiens [2]
Arylsulfatase B (ARSB) DME Info Homo sapiens [2]
Butyrylcholine esterase (BCHE) DME Info Homo sapiens [2]
Choline dehydrogenase (CHDH) DME Info Homo sapiens [2]
Cholesterol desmolase (CYP11A1) DME Info Homo sapiens [3]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [4]
Leukotriene B4 omega-hydroxylase (CYP4F3) DME Info Homo sapiens [3]
Dicarbonyl/L-xylulose reductase (DCXR) DME Info Homo sapiens [2]
Delta(24)-sterol reductase (DHCR24) DME Info Homo sapiens [2]
Dihydrofolate reductase (DHFR) DME Info Homo sapiens [2]
Dipeptidyl peptidase IV (DPP4) DME Info Homo sapiens [2]
Dihydrothymine dehydrogenase (DPYD) DME Info Homo sapiens [2]
Fatty acid desaturase 1 (FADS1) DME Info Homo sapiens [2]
Glutamine synthetase (GLUL) DME Info Homo sapiens [1]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [2]
Estradiol 17-beta-dehydrogenase 1 (HSD17B1) DME Info Homo sapiens [4]
Iduronate 2-sulfatase (IDS) DME Info Homo sapiens [2]
Methionine-tRNA ligase mitochondrial (MARS2) DME Info Homo sapiens [4], [2]
S-adenosylmethionine synthase 2 (MAT2A) DME Info Homo sapiens [4], [2]
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [2]
Methionine-R-sulfoxide reductase B1 (MSRB1) DME Info Homo sapiens [2]
Vitamin B12 methionine synthase (MTR) DME Info Homo sapiens [2]
Mevalonate pyrophosphate decarboxylase (MPD) DME Info Homo sapiens [2]
Methylarsonite methyltransferase N6AMT1 (N6AMT1) DME Info Homo sapiens [2]
RNA cytidine acetyltransferase (hALP) DME Info Homo sapiens [2]
Ecto-5'-nucleotidase (NT5E) DME Info Homo sapiens [3]
Phosphorylethanolamine transferase (PCYT2) DME Info Homo sapiens [2]
Phosphoribosylformylglycinamidine synthase (PFAS) DME Info Homo sapiens [2]
Phosphoglucomutase 1 (PGM1) DME Info Homo sapiens [2]
Xylosyl phosphatase (PXYLP1) DME Info Homo sapiens [2]
Selenocysteine lyase (SCLY) DME Info Homo sapiens [2]
Transglutaminase H (TGM2) DME Info Homo sapiens [3]
VKORC1-like protein 1 (VKORC1L1) DME Info Homo sapiens [2]
Tryptophanyl-tRNA synthetase mitochondrial (WARS2) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Alcohol dehydrogenase class-II (ADH4) DME Info Homo sapiens [2]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [4], [5]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [3]
Aldo-keto reductase 1D1 (AKR1D1) DME Info Homo sapiens [2]
Aminomuconic semialdehyde dehydrogenase (ALDH12) DME Info Homo sapiens [2]
Arachidonate 12-lipoxygenase (ALOX12B) DME Info Homo sapiens [1]
Alkaline phosphatase (ALPL) DME Info Homo sapiens [6]
Copper amine oxidase (AOC3) DME Info Homo sapiens [2]
Asparagine synthetase (ASNS) DME Info Homo sapiens [1]
Cytosolic branched aminotransferase (BCAT1) DME Info Homo sapiens [1], [2]
Serine sulfhydrase (CBS) DME Info Homo sapiens [1]
Cytidine aminohydrolase (CDA) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [5]
Cytochrome P450 4F12 (CYP4F12) DME Info Homo sapiens [2]
Cytochrome P450 4F2 (CYP4F2) DME Info Homo sapiens [2]
L-glutamine amidohydrolase (GLS) DME Info Homo sapiens [4], [2]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [2]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [7]
Ketoacyl-CoA reductase (HSD17B12) DME Info Homo sapiens [2]
Dihydrotestosterone oxidoreductase (HSD3B1) DME Info Homo sapiens [3]
Glutamine-dependent NAD(+) synthetase (NADSYN1) DME Info Homo sapiens [2]
N-acetyltransferase 1 (NAT1) DME Info Homo sapiens [2]
Choline phosphatase 1 (PLD1) DME Info Homo sapiens [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [1], [4]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [2]
Sulfotransferase 1A1 (SULT1A1) DME Info Homo sapiens [2]
Sulfotransferase 2B1 (SULT2B1) DME Info Homo sapiens [3]
Thymidine phosphorylase (TYMP) DME Info Homo sapiens [7], [2]
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info Homo sapiens [2]
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME Info Homo sapiens [2]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [1]
Xanthine dehydrogenase/oxidase (XDH) DME Info Homo sapiens [1]
References
1 Cystathionine metabolic enzymes play a role in the inflammation resolution of human keratinocytes in response to sub-cytotoxic formaldehyde exposure. Toxicol Appl Pharmacol. 2016 Nov 1;310:185-194.
2 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
3 Regulation of chromatin assembly and cell transformation by formaldehyde exposure in human cells. Environ Health Perspect. 2017 Sep 21;125(9):097019.
4 Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro. Toxicol Lett. 2010 Oct 5;198(2):289-95.
5 A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
6 Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry. Odontology. 2013 Jan;101(1):43-51.
7 Identification of formaldehyde-responsive genes by suppression subtractive hybridization. Toxicology. 2008 Jan 14;243(1-2):224-35.

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