Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01325)
Xenobiotics Name
GW-3965
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Preclinical/Patented Drug
Structure
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3D MOL 2D MOL
PubChem CID
447905
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cholesterol desmolase (CYP11A1) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [2]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [3]
References
1 Inhibition of progesterone production in human luteinized granulosa cells treated with LXR agonists. Mol Hum Reprod. 2007 Jun;13(6):373-9.
2 Liver X receptor alpha bidirectionally transactivates human CYP1A1 and CYP1A2 through two cis-elements common to both genes. Toxicol Lett. 2012 Nov 23;215(1):16-24.
3 Dual roles of nuclear receptor liver X receptor alpha (LXRalpha) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator. Biochem Pharmacol. 2013 Aug 1;86(3):428-36.

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