Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01335)
Xenobiotics Name
Hyperforin
Xenobiotics Type
Natural Product(s), Extract(s) or Medicine(s)
Classification
Natural Product
Structure
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3D MOL 2D MOL
PubChem CID
441298
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [1]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info Homo sapiens [3]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [4]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [5]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [4]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [4]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [4]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 3A4 (CYP3A4) DME Info IC50 = 2.3 microM [2]
References
1 StJohn's wort extracts and some of their constituents potently inhibit ultimate carcinogen formation from benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1. Cancer Res. 2003 Nov 15;63(22):8062-8.
2 Lessons learned from herbal medicinal products: the example of StJohn's Wort (perpendicular). J Nat Prod. 2010 May 28;73(5):1015-21.
3 Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia. J Clin Invest. 2005 Jan;115(1):177-86.
4 No activation of human pregnane X receptor by hyperforin-related phloroglucinols. J Pharmacol Exp Ther. 2014 Mar;348(3):393-400.
5 Induction and inhibition of cytochromes P450 by the StJohn's wort constituent hyperforin in human hepatocyte cultures. Drug Metab Dispos. 2004 May;32(5):512-8.

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