Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01397)
Xenobiotics Name
Nickel chloride
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Acute Toxic Substance
Structure
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3D MOL 2D MOL
PubChem CID
24385
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldo-keto reductase 1B1 (AKR1B1) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2], [1]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [2], [1]
Delta(24)-sterol reductase (DHCR24) DME Info Homo sapiens [3]
S-adenosylmethionine synthase 2 (MAT2A) DME Info Homo sapiens [3]
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [1]
Uridine 5'-monophosphate synthase (UMPS) DME Info Homo sapiens [2], [1]
DME(s) Induced by This Xenobiotics
Aldehyde dehydrogenase 1 (ALDH1) DME Info Homo sapiens [4]
Asparagine synthetase (ASNS) DME Info Homo sapiens [2], [1]
Metallothionein-2A (MT2A) DME Info Homo sapiens [2], [1]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [5]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [1]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [2], [1]
References
1 Patients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin. J Allergy Clin Immunol. 2015 Mar;135(3):712-20.
2 Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response. J Allergy Clin Immunol. 2014 Aug;134(2):362-72.
3 Gene expression profiles in peripheral blood mononuclear cells of Chinese nickel refinery workers with high exposures to nickel and control subjects. Cancer Epidemiol Biomarkers Prev. 2013 Feb;22(2):261-9.
4 A cross-talk between NFAT and NF-B pathways is crucial for nickel-induced COX-2 expression in Beas-2B cells. Curr Cancer Drug Targets. 2011 Jun;11(5):548-59.
5 Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells. Am J Respir Cell Mol Biol. 2009 Jul;41(1):69-75.

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