Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01418)
Xenobiotics Name
Oxidopamine
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Investigative Agent
Structure
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3D MOL 2D MOL
PubChem CID
4624
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Nitric oxide synthase brain (NOS1) DME Info Homo sapiens [2]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [3]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [4]
References
1 Involvement of pregnane X receptor in the regulation of CYP2B6 gene expression by oltipraz in human hepatocytes. Toxicol In Vitro. 2010 Mar;24(2):452-9.
2 Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines. Carcinogenesis. 2007 Feb;28(2):378-89.
3 Protection of retinal pigment epithelial cells from oxidative damage by oltipraz, a cancer chemopreventive agent. Invest Ophthalmol Vis Sci. 2002 Nov;43(11):3550-4.
4 Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3-carbinol enhance the formation and transport of benzo[a]pyrene sulfate conjugates in intestinal Caco-2 cells. Toxicol Lett. 2005 Aug 14;158(2):140-51.

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