Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01433)
Xenobiotics Name
Pirinixic acid
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Health Hazard/Toxicant
Structure
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3D MOL 2D MOL
PubChem CID
5694
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldo-keto reductase 1B1 (AKR1B1) DME Info Homo sapiens [1]
Arachidonate 5-lipoxygenase (ALOX5) DME Info Homo sapiens [2]
Catalase (CAT) DME Info Homo sapiens [3]
Carboxylesterase 1 (CES1) DME Info Homo sapiens [4]
DME(s) Induced by This Xenobiotics
Small intestine reductase (AKR1B10) DME Info Homo sapiens [5]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [6]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [7]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [8]
Lauric acid omega-hydroxylase (CYP4A11) DME Info Homo sapiens [9]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [10]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [11], [12]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info Homo sapiens [6]
UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info Homo sapiens [13]
References
1 Toxicity of xanthene food dyes by inhibition of human drug-metabolizing enzymes in a noncompetitive manner. J Environ Public Health. 2009;2009:953952.
2 Regulation of cytochrome b5 gene transcription by Sp3, GATA-6, and steroidogenic factor 1 in human adrenal NCI-H295A cells. Mol Endocrinol. 2005 Aug;19(8):2020-34.
3 Use of high-throughput enzyme-based assay with xenobiotic metabolic capability to evaluate the inhibition of acetylcholinesterase activity by organophosphorous pesticides. Toxicol In Vitro. 2019 Apr;56:93-100.
4 Human fecal water inhibits COX-2 in colonic HT-29 cells: role of phenolic compounds. J Nutr. 2005 Oct;135(10):2343-9.
5 The experimental antitumor agents Phortress and doxorubicin are equiactive against human-derived breast carcinoma xenograft models. Breast Cancer Res Treat. 2004 Sep;87(1):97-107.
6 Roles of nitric oxide in inflammatory downregulation of human cytochromes P450. Free Radic Biol Med. 2008 Mar 15;44(6):1161-8.
7 Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes. J Biochem Mol Toxicol. 2009 Jan-Feb;23(1):43-58.
8 Prediction of aryl hydrocarbon receptor-mediated enzyme induction of drugs and chemicals by mRNA quantification. Chem Res Toxicol. 1998 Dec;11(12):1447-52.
9 Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. Drug Metab Dispos. 2004 Mar;32(3):348-58.
10 Resveratrol inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. Ann N Y Acad Sci. 1999;889:214-23.
11 Effects of phenytoin on glutathione status and oxidative stress biomarker gene mRNA levels in cultured precision human liver slices. Toxicol Sci. 2001 Jan;59(1):118-26.
12 Induction of CYP3As in HepG2 cells by several drugs. Association between induction of CYP3A4 and expression of glucocorticoid receptor. Biol Pharm Bull. 2003 Apr;26(4):510-7.
13 Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes. Drug Metab Dispos. 2003 May;31(5):620-30.

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