Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01492)
Xenobiotics Name
Trichostatin A
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 1 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
444732
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Porphobilinogen synthase (ALAD) DME Info Homo sapiens [1]
Aldehyde oxidase (AOX1) DME Info Homo sapiens [2]
Histamine N-methyltransferase (HNMT) DME Info Homo sapiens [3]
Estradiol 17-beta-dehydrogenase 1 (HSD17B1) DME Info Homo sapiens [4]
Indoleamine 2,3-dioxygenase 1 (IDO1) DME Info Homo sapiens [5]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [6]
Phosphodiesterase 7B (PDE7B) DME Info Homo sapiens [7]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [3]
Thymidylate synthase (TYMS) DME Info Homo sapiens [6], [8]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [6]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [9]
Butyrylcholine esterase (BCHE) DME Info Homo sapiens [10]
Microsomal cytochrome MCB5 (CYB5A) DME Info Homo sapiens [4]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [10]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [8]
Retinoic acid 4-hydroxylase 26A1 (CYP26A1) DME Info Homo sapiens [11], [12]
Dipeptidyl peptidase IV (DPP4) DME Info Homo sapiens [6]
Dihydrothymine dehydrogenase (DPYD) DME Info Homo sapiens [3], [13]
Hexosephosphate aminotransferase 2 (GFPT2) DME Info Homo sapiens [3]
L-glutamine amidohydrolase (GLS) DME Info Homo sapiens [6]
Glutathione S-transferase omega-1 (GSTO1) DME Info Homo sapiens [14]
Iduronate 2-sulfatase (IDS) DME Info Homo sapiens [15]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [6], [10]
Microsomal glutathione S-transferase 2 (MGST2) DME Info Homo sapiens [16]
Neprilysin (MME) DME Info Homo sapiens [17]
N-acetyltransferase 2 (NAT2) DME Info Homo sapiens [8]
Ecto-5'-nucleotidase (NT5E) DME Info Homo sapiens [8]
Cytosolic phospholipase A2 (PLA2G4A) DME Info Homo sapiens [18]
Prostaglandin reductase 1 (PTGR1) DME Info Homo sapiens [4]
Sulfotransferase 1A1 (SULT1A1) DME Info Homo sapiens [6]
Transglutaminase H (TGM2) DME Info Homo sapiens [3]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [8]
References
1 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
2 Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
3 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
4 Endocrine disruption potentials of organophosphate flame retardants and related mechanisms in H295R and MVLN cell lines and in zebrafish. Aquat Toxicol. 2012 Jun 15;114-115:173-81.
5 All-trans-retinoic acid intensifies endoplasmic reticulum stress in N-acetylglucosaminyltransferase V repressed human hepatocarcinoma cells by perturbing homocysteine metabolism. J Cell Biochem. 2010 Feb 15;109(3):468-77.
6 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
7 Arachidonic acid-induced gene expression in colon cancer cells. Carcinogenesis. 2006 Oct;27(10):1950-60.
8 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
9 Immediate up-regulation of the calcium-binding protein S100P and its involvement in the cytokinin-induced differentiation of human myeloid leukemia cells. Biochim Biophys Acta. 2005 Sep 10;1745(2):156-65.
10 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
11 Retinoid receptors in human breast carcinoma: possible modulators of in situ estrogen metabolism. Breast Cancer Res Treat. 2001 Jan;65(1):31-40.
12 Organotin compounds enhance 17beta-hydroxysteroid dehydrogenase type I activity in human choriocarcinoma JAr cells: potential promotion of 17beta-estradiol biosynthesis in human placenta. Biochem Pharmacol. 2006 Apr 28;71(9):1349-57.
13 Glutathione depletion in antioxidant defense of differentiated NT2-LHON cybrids. Neurobiol Dis. 2007 Mar;25(3):536-44.
14 Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
15 Granulocyte colony-stimulating factor-induced terminal maturation of human myeloid cells is specifically associated with up-regulation of receptor-mediated function and CD10 expression. Int J Hematol. 2003 Feb;77(2):142-51.
16 Intracellular glutathione levels determine cell sensitivity to apoptosis induced by the antineoplasic agent N-(4-hydroxyphenyl) retinamide. Anticancer Res. 2005 May-Jun;25(3B):1945-51.
17 High concentrations of retinoids induce differentiation and late apoptosis in pancreatic cancer cells in vitro. Cancer Biol Ther. 2005 May;4(5):602-11.
18 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.

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