Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01505)
Xenobiotics Name
Lead
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Health Hazard/Toxicant
Structure
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3D MOL 2D MOL
PubChem CID
5352425
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Alcohol dehydrogenase class-I beta (ADH1B) DME Info Homo sapiens [1]
Porphobilinogen synthase (ALAD) DME Info Homo sapiens [2]
Aldehyde dehydrogenase 5 (ALDHX) DME Info Homo sapiens [1]
Carbonic anhydrase II (CA2) DME Info Homo sapiens [3]
Carboxylesterase 2 (CES2) DME Info Homo sapiens [1]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [1]
Glutathione S-transferase theta-1 (GSTT1) DME Info Homo sapiens [1]
Peroxisomal multifunctional enzyme 2 (HSD17B4) DME Info Homo sapiens [1]
Neprilysin (MME) DME Info Homo sapiens [4]
Glutamine-dependent NAD(+) synthetase (NADSYN1) DME Info Homo sapiens [1]
RNA cytidine acetyltransferase (hALP) DME Info Homo sapiens [1]
NADH-ubiquinone oxidoreductase 49 kDa (NDUFS2) DME Info Homo sapiens [1]
Serum paraoxonase/arylesterase 1 (PON1) DME Info Homo sapiens [5]
Xanthine dehydrogenase/oxidase (XDH) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Alcohol dehydrogenase class-II (ADH4) DME Info Homo sapiens [1]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [6]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [1]
Metallothionein-2A (MT2A) DME Info Homo sapiens [6]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [7]
Phosphodiesterase 7B (PDE7B) DME Info Homo sapiens [1]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [8]
References
1 Correlations of gene expression with blood lead levels in children with autism compared to typically developing controls. Neurotox Res. 2011 Jan;19(1):1-13.
2 Modifying effects of delta-Aminolevulinate dehydratase polymorphism on blood lead levels and ALAD activity. Toxicol Lett. 2018 Oct 1;295:351-356.
3 In vitro inhibitory effects of some heavy metals on human erythrocyte carbonic anhydrases. J Enzyme Inhib Med Chem. 2007 Dec;22(6):745-50.
4 In vitro Pb exposure disturbs the balance between Abeta production and elimination: the role of AbetaPP and neprilysin. Neurotoxicology. 2011 Jun;32(3):300-6.
5 Lead exposure is associated with decreased serum paraoxonase 1 (PON1) activity and genotypes. Environ Health Perspect. 2006 Aug;114(8):1233-6.
6 Effects of arsenic, cadmium, chromium, and lead on gene expression regulated by a battery of 13 different promoters in recombinant HepG2 cells. Toxicol Appl Pharmacol. 2000 Oct 15;168(2):79-90.
7 Transcriptional and posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by lead in HepG2 cells: a role of heme oxygenase. Toxicology. 2012 Jan 27;291(1-3):113-21.
8 Synergistic effects of amyloid peptides and lead on human neuroblastoma cells. Cell Mol Biol Lett. 2012 Sep;17(3):408-21.

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