Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01511)
Xenobiotics Name
Vitallium
Xenobiotics Type
Natural Product(s), Extract(s) or Medicine(s)
Classification
Natural Mixture
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [1], [2]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [3], [4]
Indoleamine 2,3-dioxygenase 1 (IDO1) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [1]
Vitamin D(3) 25-hydroxylase (CYP27A1) DME Info Homo sapiens [4]
Glutamine synthetase (GLUL) DME Info Homo sapiens [1]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [5]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [6]
References
1 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
2 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
3 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
4 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
5 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
6 Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.

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