Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01541)
Xenobiotics Name
Eupatorin
Xenobiotics Type
Natural Product(s), Extract(s) or Medicine(s)
Classification
Natural Product
Structure
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3D MOL 2D MOL
PubChem CID
97214
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [1]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [2], [1]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [3]
Cytochrome P450 2D6 (CYP2D6) DME Info Homo sapiens [4]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [4]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 1A1 (CYP1A1) DME Info Ki = 0.21 microM [1]
Cytochrome P450 1B1 (CYP1B1) DME Info Ki = 0.035 microM [2], [1]
References
1 Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. Bioorg Med Chem. 2011 May 1;19(9):2842-9.
2 Inhibitors of cytochrome P450 (CYP) 1B1. Eur J Med Chem. 2017 Jul 28;135:296-306.
3 In vitro modulatory effects of Andrographis paniculata, Centella asiatica and Orthosiphon stamineus on cytochrome P450 2C19 (CYP2C19). J Ethnopharmacol. 2011 Jan 27;133(2):881-7.
4 In vitro effects of active constituents and extracts of Orthosiphon stamineus on the activities of three major human cDNA-expressed cytochrome P450 enzymes. Chem Biol Interact. 2011 Mar 15;190(1):1-8.

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