Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01582)
Xenobiotics Name
Pyrrolizidine alkaloid
Xenobiotics Type
Natural Product(s), Extract(s) or Medicine(s)
Classification
Natural Product
Structure
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3D MOL 2D MOL
PubChem CID
333469
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Alcohol dehydrogenase class-I alpha (ADH1A) DME Info Homo sapiens [1]
Aminomuconic semialdehyde dehydrogenase (ALDH12) DME Info Homo sapiens [2]
Arsenite methyltransferase (AS3MT) DME Info Homo sapiens [3]
Vitamin D(3) 25-hydroxylase (CYP27A1) DME Info Homo sapiens [4]
Dihydrothymine dehydrogenase (DPYD) DME Info Homo sapiens [5]
Dimethylaniline oxidase 3 (FMO3) DME Info Homo sapiens [4]
Histamine N-methyltransferase (HNMT) DME Info Homo sapiens [6]
Monoamine oxidase type B (MAO-B) DME Info Homo sapiens [4]
Microsomal glutathione S-transferase 2 (MGST2) DME Info Homo sapiens [7]
Sulfotransferase 1E1 (SULT1E1) DME Info Homo sapiens [5]
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME Info Homo sapiens [8]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [4]
Calcidiol 1-monooxygenase (CYP27B1) DME Info Homo sapiens [4]
References
1 The beta-adrenoceptor antagonist, propranolol, induces human gastric cancer cell apoptosis and cell cycle arrest via inhibiting nuclear factor B signaling. Oncol Rep. 2010 Dec;24(6):1669-76.
2 Parabens inhibit fatty acid amide hydrolase: a potential role in paraben-enhanced 3T3-L1 adipocyte differentiation. Toxicol Lett. 2016 Nov 16;262:92-99.
3 Effect of vicanicin and protolichesterinic acid on human prostate cancer cells: role of Hsp70 protein. Chem Biol Interact. 2012 Jan 5;195(1):1-10.
4 Integrated analysis of microRNA and mRNA expression profiles highlights aldehyde-induced inflammatory responses in cells relevant for lung toxicity. Toxicology. 2015 Aug 6;334:111-21.
5 Effects of beta-estradiol and propofol on the 4-methylumbelliferone glucuronidation in recombinant human UGT isozymes 1A1, 1A8 and 1A9. Biopharm Drug Dispos. 2004 Nov;25(8):339-44.
6 beta2-adrenergic antagonists suppress pancreatic cancer cell invasion by inhibiting CREB, NFB and AP-1. Cancer Biol Ther. 2010 Jul 1;10(1):19-29.
7 Examining the genomic influence of skin antioxidants in vitro. Mediators Inflamm. 2010;2010.
8 Evaluation of cytotoxicity of propofol and its related mechanism in glioblastoma cells and astrocytes. Environ Toxicol. 2017 Dec;32(12):2440-2454.

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