Drug Information

Drug General Information
Drug ID
D05WQO
Former ID
DIB019201
Drug Name
compound 11
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527967]
Formula
C25H21N5O6
InChI
InChI=1S/C25H21N5O6/c26-22(27)12-4-5-18-19(9-12)30-24(29-18)17-8-14(16(25(35)36)10-20(31)32)7-15(21(17)33)11-2-1-3-13(6-11)23(28)34/h1-9,16,29-30H,10H2,(H3,26,27)(H2,28,34)(H,31,32)(H,35,36)/b24-17+
InChIKey
WFPGMUDIBWJJND-JJIBRWJFSA-N
PubChem Compound ID
44410198
PubChem Substance ID
103485471, 104065597, 232124251, 252166701
Target and Pathway
Target(s) Coagulation factor VII Target Info Inhibitor [527967]
mRNA of Plasma kallikrein Target Info Inhibitor [527967]
KEGG Pathway Complement and coagulation cascadeshsa04610:Complement and coagulation cascades
NetPath Pathway AndrogenReceptor Signaling Pathway
PANTHER Pathway Angiogenesis
Blood coagulationP00011:Blood coagulation
PathWhiz Pathway CoagulationPW000562:Coagulation
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expression
Extrinsic Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteinsR-HSA-140837:Intrinsic Pathway of Fibrin Clot Formation
Activation of Matrix Metalloproteinases
WikiPathways Complement and Coagulation Cascades
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
Blood Clotting Cascade
Formation of Fibrin Clot (Clotting Cascade)
Circadian Clock
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient NetworkWP558:Complement and Coagulation Cascades
Human Complement System
References
Ref 527967Small molecule inhibitors of plasma kallikrein. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2034-6. Epub 2006 Jan 18.
Ref 527967Small molecule inhibitors of plasma kallikrein. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2034-6. Epub 2006 Jan 18.

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