Drug Information

Drug General Information
Drug ID
D0A7AK
Former ID
DNC006912
Drug Name
3-{[2-(2-phenylethyl)phenoxy]methyl}pyridine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528493]
Formula
C20H19NO
Canonical SMILES
C1=CC=C(C=C1)CCC2=CC=CC=C2OCC3=CN=CC=C3
InChI
1S/C20H19NO/c1-2-7-17(8-3-1)12-13-19-10-4-5-11-20(19)22-16-18-9-6-14-21-15-18/h1-11,14-15H,12-13,16H2
InChIKey
WUVSQVHZKKJEHX-UHFFFAOYSA-N
PubChem Compound ID
11973810
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Inhibitor [528493]
D(2) dopamine receptor Target Info Inhibitor [528493]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04015:Rap1 signaling pathway
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 528493J Med Chem. 2006 Nov 2;49(22):6607-13.Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition.
Ref 528493J Med Chem. 2006 Nov 2;49(22):6607-13.Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.