Drug Information

Drug General Information
Drug ID
D0B3XG
Former ID
DIB003303
Drug Name
Recombinant von Willebrand factor/recombinant Factor VIII complex
Synonyms
Willebrand factor/recombinant Factor VIII complex; Recombinant von Willebrand factor/recombinant Factor VIII complex (von Willebrand disease)
Indication Von willebrand disease [ICD10:D68.0] Phase 3 [525418]
Company
Csl behring
Target and Pathway
Target(s) Von Willebrand factor Target Info Modulator [544151]
Coagulation Factor VIIIa Target Info Modulator [544151]
KEGG Pathway PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Complement and coagulation cascades
Platelet activationhsa04610:Complement and coagulation cascades
PANTHER Pathway Blood coagulation
Inflammation mediated by chemokine and cytokine signaling pathwayP00011:Blood coagulation
PathWhiz Pathway Coagulation
Reactome Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Integrin cell surface interactions
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
GP1b-IX-V activation signalling
MAP2K and MAPK activation
Platelet Adhesion to exposed collagenR-HSA-114608:Platelet degranulation
Common Pathway of Fibrin Clot Formation
COPII (Coat Protein 2) Mediated Vesicle Transport
Cargo concentration in the ER
WikiPathways Complement and Coagulation Cascades
Focal Adhesion
Blood Clotting Cascade
Platelet Adhesion to exposed collagen
Integrin alphaIIb beta3 signaling
GP1b-IX-V activation signalling
Formation of Fibrin Clot (Clotting Cascade)WP558:Complement and Coagulation Cascades
Formation of Fibrin Clot (Clotting Cascade)
References
Ref 525418FcRn Rescues Recombinant Factor VIII Fc Fusion Protein from a VWF Independent FVIII Clearance Pathway in Mouse Hepatocytes. PLoS One. 2015 Apr 23;10(4):e0124930.
Ref 5441516 Factor VIII Concentrates, Factor VIII/von Willebrand Factor Concentrates, Factor IX Concentrates, Activated Prothrombin Complex Concentrates. Transfus Med Hemother. 2009 December; 36(6): 409-418.

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