Drug Information

Drug General Information
Drug ID
D0H4XV
Former ID
DIB016718
Drug Name
IM0-8400
Indication Diffuse large B-cell lymphoma [ICD9: 200; ICD10:C83.3] Discontinued in Phase 1/2 [550999]
Company
Idera pharmaceuticals
Target and Pathway
Target(s) Toll-like receptor 9 Target Info Antagonist [551000]
Toll-like receptor 8 Target Info Antagonist [551000]
Toll-like receptor 7 Target Info Antagonist [551000]
KEGG Pathway Toll-like receptor signaling pathway
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Malaria
Tuberculosis
Measles
Herpes simplex infectionhsa04620:Toll-like receptor signaling pathwayhsa04620:Toll-like receptor signaling pathway
Influenza A
NetPath Pathway BCR Signaling PathwayNetPath_22:Leptin Signaling Pathway
TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathwayP00054:Toll receptor signaling pathwayP00054:Toll receptor signaling pathway
Reactome PI3K Cascade
Trafficking and processing of endosomal TLR
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosomeR-HSA-1679131:Trafficking and processing of endosomal TLR
MyD88 dependent cascade initiated on endosome
WikiPathways Toll-like receptor signaling pathway
Toll-Like Receptors Cascades
MyD88 dependent cascade initiated on endosome
Trafficking and processing of endosomal TLR
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
Regulation of toll-like receptor signaling pathway
References
Ref 550999Clinical pipeline report, company report or official report of Idera Pharmaceuticals.
Ref 551000Clinical pipeline report, company report or official report of Idera Pharmaceuticals.

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