Drug Information

Drug General Information
Drug ID
D0VP6M
Former ID
DNC003700
Drug Name
1-(3,3-Dimethyl-2-oxo-butyl)-1H-indole-2,3-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [525916]
Formula
C14H15NO3
Canonical SMILES
CC(C)(C)C(=O)CN1C2=CC=CC=C2C(=O)C1=O
InChI
1S/C14H15NO3/c1-14(2,3)11(16)8-15-10-7-5-4-6-9(10)12(17)13(15)18/h4-7H,8H2,1-3H3
InChIKey
GGQBSDZGSYIVQW-UHFFFAOYSA-N
PubChem Compound ID
3659236
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [525916]
Plasminogen Target Info Inhibitor [525916]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosushsa04080:Neuroactive ligand-receptor interaction
Complement and coagulation cascades
Staphylococcus aureus infection
Influenza A
PANTHER Pathway Blood coagulation
Plasminogen activating cascade
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling
p75(NTR)-mediated signaling
amb2 Integrin signaling
Syndecan-4-mediated signaling events
PathWhiz Pathway Coagulation
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix MetalloproteinasesR-HSA-114608:Platelet degranulation
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Dissolution of Fibrin Clot
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagenWP558:Complement and Coagulation Cascades
Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Activation of Matrix Metalloproteinases
Blood Clotting Cascade
Dissolution of Fibrin Clot
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 525916Bioorg Med Chem Lett. 2000 Nov 20;10(22):2501-4.Parallel synthesis of isatin-based serine protease inhibitors.
Ref 525916Bioorg Med Chem Lett. 2000 Nov 20;10(22):2501-4.Parallel synthesis of isatin-based serine protease inhibitors.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.