Drug Information

Drug General Information
Drug ID
D0ZT8D
Former ID
DNC012052
Drug Name
TRAMAZOLINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533545]
Formula
C13H17N3
Canonical SMILES
C1CCC2=C(C1)C=CC=C2NC3=NCCN3
InChI
1S/C13H17N3/c1-2-6-11-10(4-1)5-3-7-12(11)16-13-14-8-9-15-13/h3,5,7H,1-2,4,6,8-9H2,(H2,14,15,16)
InChIKey
QQJLHRRUATVHED-UHFFFAOYSA-N
CAS Number
CAS 1082-57-1
PubChem Compound ID
5524
SuperDrug ATC ID
R01AA09
Target and Pathway
Target(s) Alpha-2A adrenergic receptor Target Info Inhibitor [533545]
Alpha-2B adrenergic receptor Target Info Inhibitor [533545]
Alpha-2C adrenergic receptor Target Info Inhibitor [533545]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signaling
References
Ref 533545J Med Chem. 1982 Dec;25(12):1389-401.alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs.
Ref 533545J Med Chem. 1982 Dec;25(12):1389-401.alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs.

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