Drug Information

Drug General Information
Drug ID
D09BIV
Former ID
DNC012438
Drug Name
TRACIZOLINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526918]
Formula
C15H18N2O6
PubChem Compound ID
6455103
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Inhibitor [526918]
Amine oxidase [flavin-containing] A Target Info Inhibitor [526918]
Alpha-2B adrenergic receptor Target Info Inhibitor [526918]
Amine oxidase [flavin-containing] B Target Info Inhibitor [526918]
Alpha-2A adrenergic receptor Target Info Inhibitor [526918]
BioCyc Pathway Superpathway of tryptophan utilization
Dopamine degradation
Putrescine degradation III
Noradrenaline and adrenaline degradation
Serotonin degradation
Superpathway of melatonin degradation
Melatonin degradation IIPWY66-401:Superpathway of tryptophan utilization
Tryptophan degradation via tryptamine
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa00260:Glycine, serine and threonine metabolism
Arginine and proline metabolism
Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Tryptophan metabolism
Drug metabolism - cytochrome P450
Metabolic pathways
Serotonergic synapse
Dopaminergic synapse
Cocaine addiction
Amphetamine addiction
Alcoholismhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00001:Adrenaline and noradrenaline biosynthesis
5-Hydroxytryptamine degredation
Dopamine receptor mediated signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
PathWhiz Pathway Histidine Metabolism
Tyrosine Metabolism
Glycine and Serine Metabolism
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-181430:Norepinephrine Neurotransmitter Release CycleR-HSA-390696:Adrenoceptors
G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Oxidative Stress
Dopamine metabolism
Phase 1 - Functionalization of compounds
Neurotransmitter Release Cycle
Neurotransmitter Clearance In The Synaptic Cleft
Serotonin Transporter ActivityWP58:Monoamine GPCRs
GPCR downstream signalingWP465:Tryptophan metabolism
Phase 1 - Functionalization of compoundsWP58:Monoamine GPCRs
GPCR downstream signaling
References
Ref 526918Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9.Binding of an imidazopyridoindole at imidazoline I2 receptors.
Ref 526918Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9.Binding of an imidazopyridoindole at imidazoline I2 receptors.

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