Drug Information

Drug General Information
Drug ID
D0V9ND
Former ID
DPR000072
Drug Name
MCP-1
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Preclinical [536223]
Company
Pfizer
Target and Pathway
Target(s) C-C chemokine receptor type 2 Target Info Antagonist [536223]
C-C motif chemokine 2 Target Info Inhibitor [536223]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathwayhsa04060:Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NOD-like receptor signaling pathway
TNF signaling pathway
Chagas disease (American trypanosomiasis)
Malaria
Influenza A
Herpes simplex infection
Rheumatoid arthritis
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
RANKL Signaling PathwayNetPath_20:IL9 Signaling Pathway
IL5 Signaling Pathway
IL1 Signaling Pathway
TSH Signaling Pathway
TWEAK Signaling Pathway
IL4 Signaling Pathway
TNFalpha Signaling Pathway
TSLP Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database GMCSF-mediated signaling events
Validated transcriptional targets of AP1 family members Fra1 and Fra2
AP-1 transcription factor network
IL23-mediated signaling events
Reactome Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling eventsR-HSA-380108:Chemokine receptors bind chemokines
ATF4 activates genes
WikiPathways GPCRs, Class A Rhodopsin-like
Defensins
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP2865:IL1 and megakaryotyces in obesity
Activation of Genes by ATF4
Oncostatin M Signaling Pathway
TNF alpha Signaling Pathway
TWEAK Signaling Pathway
IL-1 signaling pathway
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 536223Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
Ref 536223Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.

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