Drug Information

Drug General Information
Drug ID
D02PAU
Former ID
DNC007525
Drug Name
ZK-814048
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528872]
Formula
C20H17Cl3N4O3S
Canonical SMILES
CNCC1=CSC(=C1Cl)C(=O)NC2=C(C=C(C=C2C(=O)NC3=NC=C(C=C3)C<br />l)Cl)OC
InChI
1S/C20H17Cl3N4O3S/c1-24-7-10-9-31-18(16(10)23)20(29)27-17-13(5-12(22)6-14(17)30-2)19(28)26-15-4-3-11(21)8-25-15/h3-6,8-9,24H,7H2,1-2H3,(H,27,29)(H,25,26,28)
InChIKey
CYFNXPSIQONWKY-UHFFFAOYSA-N
PubChem Compound ID
16731825
Target and Pathway
Target(s) Coagulation factor Xa Target Info Inhibitor [528872]
Leukocyte elastase Target Info Inhibitor [528872]
Plasma kallikrein Target Info Inhibitor [528872]
KEGG Pathway Complement and coagulation cascadeshsa05202:Transcriptional misregulation in cancer
Systemic lupus erythematosushsa04610:Complement and coagulation cascades
NetPath Pathway AndrogenReceptor Signaling Pathway
PANTHER Pathway Blood coagulationP00011:Blood coagulation
Pathway Interaction Database Beta2 integrin cell surface interactionsupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
PathWhiz Pathway CoagulationPW000562:Coagulation
Reactome Extrinsic Pathway of Fibrin Clot Formation
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteinsR-HSA-1442490:Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix MetalloproteinasesR-HSA-140837:Intrinsic Pathway of Fibrin Clot Formation
Activation of Matrix Metalloproteinases
WikiPathways Complement and Coagulation Cascades
Human Complement System
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
Blood Clotting Cascade
Formation of Fibrin Clot (Clotting Cascade)WP2840:Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Degradation of collagenWP558:Complement and Coagulation Cascades
Formation of Fibrin Clot (Clotting Cascade)
References
Ref 528872J Med Chem. 2007 Jun 28;50(13):2967-80. Epub 2007 May 31.Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors.
Ref 528872J Med Chem. 2007 Jun 28;50(13):2967-80. Epub 2007 May 31.Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors.

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