Drug Information

Drug General Information
Drug ID
D0D2SE
Former ID
DNC010830
Drug Name
(Z)-1,1,1,2,2,3,3-heptafluorohenicos-12-en-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530831]
Formula
C21H33F7O
Canonical SMILES
CCCCCCCCC=CCCCCCCCC(=O)C(C(C(F)(F)F)(F)F)(F)F
InChI
1S/C21H33F7O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(29)19(22,23)20(24,25)21(26,27)28/h9-10H,2-8,11-17H2,1H3/b10-9-
InChIKey
CAINANTZOVVNLF-KTKRTIGZSA-N
PubChem Compound ID
25137229
Target and Pathway
Target(s) Cytosolic phospholipase A2 Target Info Inhibitor [530831]
BioCyc Pathway Phospholipases
KEGG Pathway Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Metabolic pathways
MAPK signaling pathway
Ras signaling pathway
Vascular smooth muscle contraction
VEGF signaling pathway
Platelet activation
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Glutamatergic synapse
Serotonergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Ovarian steroidogenesis
Oxytocin signaling pathway
Choline metabolism in cancer
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Angiogenesis
Endothelin signaling pathway
Inflammation mediated by chemokine and cytokine signaling pathway
Oxidative stress response
VEGF signaling pathway
CCKR signaling map ST
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
Endothelins
PDGFR-beta signaling pathway
Signaling mediated by p38-alpha and p38-beta
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
Reactome Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PI
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
WikiPathways Prostaglandin Synthesis and Regulation
p38 MAPK Signaling Pathway
Glycerophospholipid biosynthesis
Arachidonic acid metabolism
PDGF Pathway
Integrated Pancreatic Cancer Pathway
AGE/RAGE pathway
Opioid Signalling
Signal amplification
Platelet homeostasis
References
Ref 530831J Med Chem. 2010 May 13;53(9):3602-10.Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.
Ref 530831J Med Chem. 2010 May 13;53(9):3602-10.Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.

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