| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI
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| Oligomerization |
| Cytochrome b5 (CYB5A) |
Health |
Heterooligomer |
| Uniprot ID |
|
| Interaction Name |
CYB5A, POR and CYP1A2 heterooligomerization |
[1] |
| Studied Cell Lines |
Whole-BTC cell line |
| Activity |
Km = 0.6 microM |
| Description |
Cytochrome b5 (CYB5A) and NADPH-CYP450 reductase (POR) are reported to heterooligomerize with the CYP1A2 gene, which is necessary for sustaining the enzyme activity of Cytochrome P450 1A2. As a result, the interaction among CYB5A, POR and CYP1A2 is necessary for sustaining the drug-metabolizing process of Cytochrome P450 1A2. |
| Cytochrome P450 2E1 (CYP2E1) |
Health |
Heterooligomer |
| Uniprot ID |
|
| Interaction Name |
CYP2E1-CYP1A2 heterooligomerization |
[2] |
| Studied Cell Lines |
Escherichia coli cell line |
| Affected Substrate(s): |
7-Ethoxyresorufin (Metabolic product: Dealkylation of 7-ethoxyresorufin)
|
| Description |
Cytochrome P450 2E1 (CYP2E1) is reported to heterooligomerize with the CYP1A2 protein, which leads to an increased activity of the drug-metabolizing enzyme Cytochrome P450 1A2. As a result, the interaction between CYP2E1 and CYP1A2 can facilitate the drug-metabolizing process of Cytochrome P450 1A2. |
| NADPH-CYP450 reductase (POR) |
Health |
Heterooligomer |
| Uniprot ID |
|
| Interaction Name |
POR, CYB5A and CYP1A2 heterooligomerization |
[1] |
| Studied Cell Lines |
Whole-BTC cell line |
| Activity |
Km = 0.6 microM |
| Description |
NADPH-CYP450 reductase (POR) and Cytochrome b5 (CYB5A) are reported to heterooligomerize with the CYP1A2 gene, which is necessary for sustaining the enzyme activity of Cytochrome P450 1A2. As a result, the interaction among POR, CYB5A and CYP1A2 is necessary for sustaining the drug-metabolizing process of Cytochrome P450 1A2. |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C77 Cervical cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Histone modification |
| Histone deacetylases (HDACs) |
Cervical cancer |
Repression |
| Uniprot ID |
|
| Interaction Name |
HDACs-CYP1A2 interaction |
[3] |
| Studied Cell Lines |
HeLa cell line |
| Description |
Histone deacetylases (HDACs) are reported to deacetylate the CYP1A2 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Cytochrome P450 1A2. As a result, the interaction between HDACs and CYP1A2 can inhibit the drug-metabolizing process of Cytochrome P450 1A2. |
| ICD Disease Classification 16 Genitourinary system diseases |
| ICD-11: GA33 Recurrent miscarriage |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| DNA methylation |
| DNA methyltransferase (DNMT) |
Recurrent miscarriage |
Significant hypermethylation |
| Uniprot ID |
|
| Interaction Name |
DNMT-CYP1A2 interaction |
[4] |
| Studied Cell Lines |
Placental villi |
| Description |
DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CYP1A2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cytochrome P450 1A2. As a result, the interaction between DNMT and CYP1A2 can significantly affect the drug-metabolizing process of Cytochrome P450 1A2. |
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