| General Information of Drug-Metabolizing Enzyme (DME ID: DME0060) |
| DME Name |
Adenosine aminohydrolase (ADA), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 3.5.4.4 (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amidine hydrolase
EC: 3.5.4.4
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2B62 Tongue squamous cell carcinoma |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Non-coding RNA regulation |
| hsa-miR-140-5p |
Tongue squamous cell carcinoma |
Suppression |
| miRBase ID |
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| Interaction Name |
hsa-miR-140-5p--ADA regulation |
[1] |
| Studied Cell Lines |
Tongue squamous cell carcinoma cells |
| Description |
hsa-miR-140-5p is reported to suppress ADA mRNA translation by binding to the 3' untranslated region (3'UTR) of ADA mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Adenosine aminohydrolase. |
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| References |
| 1 |
Reciprocal effects between microRNA-140-5p and ADAM10 suppress migration and invasion of human tongue cancer cells. Biochem Biophys Res Commun. 2014 Jun 6;448(3):308-14.
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