| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 01 Infectious/parasitic diseases |
| ICD-11: 1C62 Burkitt lymphoma |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Transcription-factor regulation |
| Proto-oncogene c-Myc (MYC) |
Burkitt lymphoma |
Repression |
| Uniprot ID |
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| Interaction Name |
MYC-PRODH interaction |
[1] |
| Studied Cell Lines |
P493 cell line |
| Ensembl ID |
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| Description |
Proto-oncogene c-Myc (MYC) is reported to repress the transcription of PRODH gene, which leads to a decreased expression of the drug-metabolizing enzyme Proline dehydrogenase 1. As a result, the interaction between MYC and PRODH can repress the drug-metabolizing process of Proline dehydrogenase 1. |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C82 Prostate cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Transcription-factor regulation |
| Proto-oncogene c-Myc (MYC) |
Prostate cancer |
Repression |
| Uniprot ID |
|
| Interaction Name |
MYC-PRODH interaction |
[1] |
| Studied Cell Lines |
PC3 cell line |
| Ensembl ID |
|
| Description |
Proto-oncogene c-Myc (MYC) is reported to repress the transcription of PRODH gene, which leads to a decreased expression of the drug-metabolizing enzyme Proline dehydrogenase 1. As a result, the interaction between MYC and PRODH can repress the drug-metabolizing process of Proline dehydrogenase 1. |
| ICD-11: 2C90 Renal cell carcinoma |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Non-coding RNA regulation |
| hsa-miR-23b-5p |
Renal cell carcinoma |
Suppression |
| miRBase ID |
|
| Interaction Name |
hsa-miR-23b-5p--PRODH regulation |
[2] |
| Studied Cell Lines |
786-0, TK10 and UO31 cell lines |
| Description |
hsa-miR-23b-5p is reported to suppress PRODH mRNA translation by binding to the 3' untranslated region (3'UTR) of PRODH mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Proline dehydrogenase 1. |
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