Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME0207)
DME Name Proline dehydrogenase 1 (PRODH), Homo sapiens
Synonyms Proline oxidase; Proline oxidase 2; Mitochondrial proline dehydrogenase 1; p53-induced gene 6 protein; PIG6; POX2; PRODH; PRODH2
Gene Name PRODH
UniProt ID
PROD_HUMAN
Gene ID
5625
EC Number    EC: 1.5.5.2     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
Quinone acceptor oxidoreductase
EC: 1.5.5.2
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MALRRALPALRPCIPRFVQLSTAPASREQPAAGPAAVPGGGSATAVRPPVPAVDFGNAQE
AYRSRRTWELARSLLVLRLCAWPALLARHEQLLYVSRKLLGQRLFNKLMKMTFYGHFVAG
EDQESIQPLLRHYRAFGVSAILDYGVEEDLSPEEAEHKEMESCTSAAERDGSGTNKRDKQ
YQAHRAFGDRRNGVISARTYFYANEAKCDSHMETFLRCIEASGRVSDDGFIAIKLTALGR
PQFLLQFSEVLAKWRCFFHQMAVEQGQAGLAAMDTKLEVAVLQESVAKLGIASRAEIEDW
FTAETLGVSGTMDLLDWSSLIDSRTKLSKHLVVPNAQTGQLEPLLSRFTEEEELQMTRML
QRMDVLAKKATEMGVRLMVDAEQTYFQPAISRLTLEMQRKFNVEKPLIFNTYQCYLKDAY
DNVTLDVELARREGWCFGAKLVRGAYLAQERARAAEIGYEDPINPTYEATNAMYHRCLDY
VLEELKHNAKAKVMVASHNEDTVRFALRRMEELGLHPADHQVYFGQLLGMCDQISFPLGQ
AGYPVYKYVPYGPVMEVLPYLSRRALENSSLMKGTHRERQLLWLELLRRLRTGNLFHRPA
Pathway Arginine and proline metabolism (hsa00330 )
Metabolic pathways (hsa01100 )
Function This enzyme converts proline to delta-1-pyrroline-5-carboxylate.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
L-Proline
 Drug Info Approved Malnutrition ICD11: 5B50-5B71 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Proline
 Drug Info Investigative Discovery agent ICD: N.A. [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR008807 L-Proline P5C Unclear - Unclear L-Proline [1]
MR007605 Proline Delta-1-pyrroline-5-carboxylic acid Oxidation - Oxidationn Proline [3]
References
1 L-proline dehydrogenases in hyperthermophilic archaea: distribution, function, structure, and application
2 Proline metabolism and microenvironmental stress. Annu Rev Nutr. 2010 Aug 21;30:441-63.
3 Proline metabolism in cancer

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