Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0221)
DME Name Dihydrotestosterone oxidoreductase (HSD3B1), Homo sapiens DME Info
UniProt ID
3BHS1_HUMAN
EC Number    EC: 1.1.1.145     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.145
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2C75 Placenta cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Transcription factor Sp1 (SP1) Choriocarcinoma Activation
Uniprot ID
SP1_HUMAN
Interaction Name SP1-HSD3B1 interaction [1]
Studied Cell Lines Human choriocarcinoma JEG-3 cell line
Ensembl ID
ENSG00000185591
Description Transcription factor Sp1 (SP1) is reported to activate the transcription of HSD3B1 gene, which leads to an increased expression of the drug-metabolizing enzyme Dihydrotestosterone oxidoreductase. As a result, the interaction between SP1 and HSD3B1 can activate the drug-metabolizing process of Dihydrotestosterone oxidoreductase.
               ICD-11: 2D11 Adrenocortical carcinoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Transcription factor Sp1 (SP1) Adrenocortical carcinoma Activation
Uniprot ID
SP1_HUMAN
Interaction Name SP1-HSD3B1 interaction [1]
Studied Cell Lines Adrenal cortex adenocarcinoma SW13 cell line
Ensembl ID
ENSG00000185591
Description Transcription factor Sp1 (SP1) is reported to activate the transcription of HSD3B1 gene, which leads to an increased expression of the drug-metabolizing enzyme Dihydrotestosterone oxidoreductase. As a result, the interaction between SP1 and HSD3B1 can activate the drug-metabolizing process of Dihydrotestosterone oxidoreductase.
References
1 Overlapping cis-acting elements located in the first intron of the gene for type I 3 beta-hydroxysteroid dehydrogenase modulate its transcriptional activity. Mol Endocrinol. 1995 Nov;9(11):1583-97.

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