Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0336) | |||||
|---|---|---|---|---|---|
| DME Name | Cysteinyl-conjugate N-acetyltransferase (NAT8), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.3.1.80 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-NAT8 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.83E-05; delta-beta: -2.28E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the NAT8 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cysteinyl-conjugate N-acetyltransferase. As a result, the interaction between DNMT and NAT8 can moderatly affect the drug-metabolizing process of Cysteinyl-conjugate N-acetyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Myxopapillary ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-NAT8 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 7.36E-29; delta-beta: -6.00E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the NAT8 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cysteinyl-conjugate N-acetyltransferase. As a result, the interaction between DNMT and NAT8 can significantly affect the drug-metabolizing process of Cysteinyl-conjugate N-acetyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Third ventricle chordoid glioma | Moderate hypermethylation | |||
| Interaction Name | DNMT-NAT8 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.02E-02; delta-beta: 2.94E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the NAT8 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cysteinyl-conjugate N-acetyltransferase. As a result, the interaction between DNMT and NAT8 can moderatly affect the drug-metabolizing process of Cysteinyl-conjugate N-acetyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B5F Uterine carcinosarcoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Uterine carcinosarcoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-NAT8 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 8.21E-03; delta-beta: 2.14E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the NAT8 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cysteinyl-conjugate N-acetyltransferase. As a result, the interaction between DNMT and NAT8 can moderatly affect the drug-metabolizing process of Cysteinyl-conjugate N-acetyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C25 Lung cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lung cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-NAT8 interaction | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Significant hypermethylation p-value: 3.23E-02; delta-beta: 6.75E-02 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the NAT8 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cysteinyl-conjugate N-acetyltransferase. As a result, the interaction between DNMT and NAT8 can significantly affect the drug-metabolizing process of Cysteinyl-conjugate N-acetyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C73 Ovarian cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Ovarian cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-NAT8 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.38E-03; delta-beta: 3.27E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the NAT8 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cysteinyl-conjugate N-acetyltransferase. As a result, the interaction between DNMT and NAT8 can significantly affect the drug-metabolizing process of Cysteinyl-conjugate N-acetyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.