| General Information of DME (ID: DME0336) |
| DME Name |
Cysteinyl-conjugate N-acetyltransferase (NAT8), Homo sapiens
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| Synonyms |
Acetyltransferase 2; Camello-like protein 1; GLA; N-acetyltransferase 8; ATase2; CCNAT; CML1; NAT8; TSC501
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| Gene Name |
NAT8
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| UniProt ID |
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| Gene ID |
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| EC Number |
EC: 2.3.1.80 (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.80
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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Interactome(loading-time for this interactome depdends on the speed of web connection)
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Interactions between Xenobiotics and DME (XEOTIC)  Jump to Detailed Interactome Data  |
Interactions between Host Protein and DME (HOSPPI) Jump to Detailed Interactome Data |
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Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
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| Sequence |
MAPCHIRKYQESDRQWVVGLLSRGMAEHAPATFRQLLKLPRTLILLLGGPLALLLVSGSW
LLALVFSISLFPALWFLAKKPWTEYVDMTLCTDMSDITKSYLSERGSCFWVAESEEKVVG
MVGALPVDDPTLREKRLQLFHLFVDSEHRRQGIAKALVRTVLQFARDQGYSEVILDTGTI
QLSAMALYQSMGFKKTGQSFFCVWARLVALHTVHFIYHLPSSKVGSL
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| Pathway |
Glutathione metabolism (hsa00480 ) |
| Metabolic pathways (hsa01100 ) |
| Function |
This enzyme acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids. This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, it may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins.
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