Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0475) | |||||
|---|---|---|---|---|---|
| DME Name | ADP-dependent glucokinase (ADPGK), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.7.1.147 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 6 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Anaplastic pilocytic astrocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-ADPGK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.05E-15; delta-beta: -4.84E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ADPGK gene, which leads to a significantly increased expression of the drug-metabolizing enzyme ADP-dependent glucokinase. As a result, the interaction between DNMT and ADPGK can significantly affect the drug-metabolizing process of ADP-dependent glucokinase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-ADPGK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 4.42E-11; delta-beta: -2.92E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ADPGK gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme ADP-dependent glucokinase. As a result, the interaction between DNMT and ADPGK can moderatly affect the drug-metabolizing process of ADP-dependent glucokinase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Vestibular melanotic schwannoma | Significant hypomethylation | |||
| Interaction Name | DNMT-ADPGK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.86E-04; delta-beta: -4.18E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ADPGK gene, which leads to a significantly increased expression of the drug-metabolizing enzyme ADP-dependent glucokinase. As a result, the interaction between DNMT and ADPGK can significantly affect the drug-metabolizing process of ADP-dependent glucokinase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Third ventricle chordoid glioma | Significant hypomethylation | |||
| Interaction Name | DNMT-ADPGK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.30E-07; delta-beta: -3.92E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ADPGK gene, which leads to a significantly increased expression of the drug-metabolizing enzyme ADP-dependent glucokinase. As a result, the interaction between DNMT and ADPGK can significantly affect the drug-metabolizing process of ADP-dependent glucokinase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Anaplastic pleomorphic xanthoastrocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-ADPGK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.88E-10; delta-beta: -4.48E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ADPGK gene, which leads to a significantly increased expression of the drug-metabolizing enzyme ADP-dependent glucokinase. As a result, the interaction between DNMT and ADPGK can significantly affect the drug-metabolizing process of ADP-dependent glucokinase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Peripheral neuroectodermal tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-ADPGK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.04E-02; delta-beta: -2.25E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ADPGK gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme ADP-dependent glucokinase. As a result, the interaction between DNMT and ADPGK can moderatly affect the drug-metabolizing process of ADP-dependent glucokinase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypomethylation | |||
| Interaction Name | DNMT-ADPGK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.85E-10; delta-beta: -4.09E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ADPGK gene, which leads to a significantly increased expression of the drug-metabolizing enzyme ADP-dependent glucokinase. As a result, the interaction between DNMT and ADPGK can significantly affect the drug-metabolizing process of ADP-dependent glucokinase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B60 Squamous cell carcinoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Squamous cell carcinoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-ADPGK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 4.85E-04; delta-beta: -2.13E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ADPGK gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme ADP-dependent glucokinase. As a result, the interaction between DNMT and ADPGK can moderatly affect the drug-metabolizing process of ADP-dependent glucokinase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C90 Renal cell carcinoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Renal cell carcinoma | Significant hypermethylation | |||
| Interaction Name | DNMT-ADPGK interaction | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Significant hypermethylation p-value: 1.98E-04; delta-beta: 2.30E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ADPGK gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme ADP-dependent glucokinase. As a result, the interaction between DNMT and ADPGK can significantly affect the drug-metabolizing process of ADP-dependent glucokinase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-ADPGK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 6.31E-25; delta-beta: -2.09E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ADPGK gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme ADP-dependent glucokinase. As a result, the interaction between DNMT and ADPGK can moderatly affect the drug-metabolizing process of ADP-dependent glucokinase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 11 Circulatory system diseases | |||||
| ICD-11: BB01 Pulmonary hypertension | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Pulmonary hypertension | Significant hypomethylation | |||
| Interaction Name | DNMT-ADPGK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.63E-02; delta-beta: -4.16E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ADPGK gene, which leads to a significantly increased expression of the drug-metabolizing enzyme ADP-dependent glucokinase. As a result, the interaction between DNMT and ADPGK can significantly affect the drug-metabolizing process of ADP-dependent glucokinase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: BD51 Arterial aneurysm | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Arterial aneurysm | Moderate hypomethylation | |||
| Interaction Name | DNMT-ADPGK interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.14E-02; delta-beta: -2.21E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ADPGK gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme ADP-dependent glucokinase. As a result, the interaction between DNMT and ADPGK can moderatly affect the drug-metabolizing process of ADP-dependent glucokinase. | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Moderate hypomethylation p-value: 2.36E-02; delta-beta: -2.14E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ADPGK gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme ADP-dependent glucokinase. As a result, the interaction between DNMT and ADPGK can moderatly affect the drug-metabolizing process of ADP-dependent glucokinase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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