Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1002)
DME Name Dipeptidase (pepV), Lactococcus lactis DME Info
UniProt ID
Q84BU9_LACLH
EC Number    EC: 3.4.13.-     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Peptidase
Dipeptidase
EC: 3.4.13.-
Lineage    Species: Lactococcus lactis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Lactococcus
Species: Lactococcus lactis
Subspecies: Lactococcus lactis subsp. hordniae (hT)
Subspecies: Lactococcus lactis subsp. cremoris (L6)
Subspecies: Lactococcus lactis subsp. lactis (L9)
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Enalapril Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                            Carboxylesterase 1 (CES1) Click to Show/Hide the Cometabolization Info
DME ID DME0054 DME Info
Uniprot ID
EST1_HUMAN
Interaction Name CES1-pepV interaction [1], [2]
Description The interaction, between human Carboxylesterase 1 and Dipeptidase from Lactococcus lactis which collectively metabolize the drug Enalapril, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-pepV interaction [1], [3]
Description The interaction, between human Cytochrome P450 3A4 and Dipeptidase from Lactococcus lactis which collectively metabolize the drug Enalapril, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Characterization and kinetic analysis of enzyme-substrate recognition by three recombinant lactococcal PepVs. Arch Biochem Biophys. 2006 Oct 15;454(2):137-45.
2 Absorption and cleavage of enalapril, a carboxyl ester prodrug, in the rat intestine: in vitro, in situ intestinal perfusion and portal vein cannulation models. Biopharm Drug Dispos. 2015 Sep;36(6):385-397.
3 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.

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