Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1025)
DME Name Beta-glucuronidase (uidA), Lactobacillus gasseri DME Info
UniProt ID
Q9AHJ8_LACGS
EC Number    EC: 3.2.1.31     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.31
Lineage    Species: Lactobacillus gasseri     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus gasseri
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Bazedoxifene Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                            UDP-glucuronosyltransferase 1A1 (UGT1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0004 DME Info
Uniprot ID
UD11_HUMAN
Interaction Name UGT1A1-uidA interaction [1], [2]
Description The interaction, between human UDP-glucuronosyltransferase 1A1 and Beta-glucuronidase from Lactobacillus gasseri which collectively metabolize the drug Bazedoxifene, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 1A10 (UGT1A10) Click to Show/Hide the Cometabolization Info
DME ID DME0075 DME Info
Uniprot ID
UD110_HUMAN
Interaction Name UGT1A10-uidA interaction [1], [3]
Description The interaction, between human UDP-glucuronosyltransferase 1A10 and Beta-glucuronidase from Lactobacillus gasseri which collectively metabolize the drug Bazedoxifene, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Long-term administration of conjugated estrogen and bazedoxifene decreased murine fecal beta-glucuronidase activity without impacting overall microbiome community. Sci Rep. 2018 May 25;8(1):8166.
2 UGT1A1*28 polymorphism influences glucuronidation of bazedoxifene. Pharmazie. 2015 Feb;70(2):94-6.
3 In vitro metabolism, permeability, and efflux of bazedoxifene in humans. Drug Metab Dispos. 2010 Sep;38(9):1471-9.

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