Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1025)
DME Name Beta-glucuronidase (uidA), Lactobacillus gasseri
Synonyms Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; gusA
Gene Name gusA
UniProt ID
Q9AHJ8_LACGS
EC Number    EC: 3.2.1.31     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.31
Lineage    Species: Lactobacillus gasseri     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus gasseri
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MESALYPIQNKYRFNTLMNGTWQFETDPNSVGLDEGWNKELPDPEEMPVPGTFAELTTKR
DRKYYTGDFWYQKDFFIPSFLKKKELYIRFGSVTHRAKVFINGHEVGQHEGGFLPFQVKI
SNYINYDQTNRVTVLVNNELSEKAIPCGTEEILDNGQKLAQPYFDFFNYSGIMRNVWLLA
LPQSQITNFKLNYQLANNKATITYNIEANNNAEFKVTLFDNQKEVACATSKNTSSLTIKN
PHLWSPNDPYSYKIKIEMLEDGKTVDEYTDKIGIRTVKIVNDKILLNNHPIYLKGFGKHE
DFNVLGKAVNESIIKRDYECMKWIGANCFRSSHYPYAEEWYQYADKYGFLIIDEVPAVGL
NRSITNFLNVTNSNQSHFFASKTVPELKKVHEQEIKEMIDRDQRHPSVIAWSLFNEPEST
TQESYDYFKDIFAFARKLDPQNRPYTGTLVMGSGPKVDKLHPLCDFVCLNRYYGWYVAGG
PEIVNAKKMLEDELDGWQNLKLNKPFVFTEFGADTLSSSHRLPDEMWSQEYQNEYYQMYF
DIFKKYPFICGELVWNFADFKTSEGIMRVGGNDKGIFTRDREPKDIAFTLKKRWQQLN
Function This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Bazedoxifene
 Drug Info Phase 4 Schizophrenia ICD11: 6A20 [1]
References
1 Long-term administration of conjugated estrogen and bazedoxifene decreased murine fecal beta-glucuronidase activity without impacting overall microbiome community. Sci Rep. 2018 May 25;8(1):8166.

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